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人类cGAS-STING轴和线粒体功能障碍相关疾病的分子机制:全面审查

Xingtong Shen¹, Hantao Chen¹, Jishan Zheng¹

¹Department of Immunology, Zunyi Medical University, Zunyi, China.

Current neuropharmacology

|September 29, 2025

概括

线粒体功能障碍释放DNA,激活干扰素基因 (STING) 循环GMP-AMP合成酶 (cGAS) -刺激器通路. 本综述探讨了这种疾病和治疗潜力的联系.

科学领域:

免疫学免疫学免疫学
细胞生物学细胞生物学
分子生物学分子生物学

背景情况:

线粒体对于免疫细胞功能和先天免疫是至关重要的.
该cGAS-STING通路感知细胞质DNA,影响炎症,感染,癌症和自身免疫.
线粒体功能障碍,特别是线粒体DNA (mtDNA) 释放,触发cGAS-STING信号传递.

研究的目的:

审查目前对cGAS-STING轴和线粒体功能障碍中mtDNA释放的理解.
专注于它们在疾病发病过程中的作用.
突出治疗目标和干预措施.

主要方法:

对cGAS-STING和mtDNA研究当前进展的文献综述.
分析线粒体功能障碍,cGAS-STING信号传递和疾病之间的交叉点.
综合关于治疗策略的信息.

主要成果:

线粒体功能障碍和mtDNA释放是cGAS-STING通路的强有力的激活剂.
这种cGAS-STING通路与各种疾病有关,包括神经炎症,癌症和自身免疫性疾病.
这条途径与自,新陈代谢和细胞死亡相交.

结论:

线粒体功能障碍与cGAS-STING通路之间的相互作用是疾病发病的一个重要因素.
针对cGAS-STING轴为多种疾病提供了潜在的治疗途径.
对STING激活机制的进一步研究对于开发有效的治疗方法至关重要.

关键词:

一种自身免疫性疾病.在cGAS-STING轴上缺血/再伤损伤的发生.线粒体功能障碍线粒体功能障碍分子机制的分子机制.

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