脉冲式药物输送系统的技术方面,挑战和应用 - - 批判性审查
Acharya Balkrishna1, Shalini Mishra1, Shalini Singh2
1Patanjali Herbal Research Department, Patanjali Research Foundation, Haridwar-249405, India.
Current drug delivery
|September 29, 2025
概括
脉冲式药物输送系统 (PDDS) 提供有针对性的,定时的药物释放,改善患者的服药性和各种疾病的治疗疗效. 这些系统通过提供空间和时间控制来克服持续药物输送的局限性.
科学领域:
- 制药科学 制药科学
- 药物输送系统 药物输送系统
- 生物医学工程 生物医学工程
背景情况:
- 传统的持续药物输送系统可以保持血中的水平不变,这并不总是最佳的.
- 脉冲式药物递送系统 (PDDS) 提供了对药物释放的空间和时间控制.
- PDDS通过在特定时间和地点提供药物来提高患者的遵守性和治疗结果.
研究的目的:
- 审查脉冲性药物输送系统 (PDDS) 的进展和应用.
- 讨论各种类型的PDDS,包括时间控制,刺激诱导和外部调节的系统.
- 突出PDDS在治疗具有慢性药理学模式的疾病方面的潜力.
主要方法:
- 对有关脉冲药物递送技术的现有文献的审查.
- 基于释放机制的PDDS分类 (时间控制,刺激诱导,外部调节).
- 讨论配方参数,释放特征和可用的商业产品.
主要成果:
- PDDS提供精确的药物释放控制,独立于生理条件.
- 讨论了各种系统设计,包括囊式,透式和聚合物涂层单元.
- 像Pulsincap®,OROS®,CODAS®和Pulsys®这样的商业产品证明了脉冲性分娩的可行性.
结论:
- 脉冲式药物递送系统对于需要特定释放特征的药物来说是有利的,例如具有慢药学行为或第一通代谢的药物.
- PDDS在治疗喘,心血管疾病和关节炎等疾病方面表现有前途.
- PDDS的发展代表了针对性和有效的药物治疗的重大进展.
相关概念视频
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