抗生素痴迷:对克拉里胺相关的躁狂发作进行系统审查
Tijana Marković1, Ana Todorović1, Milica Stojković1,2
1Department of Pharmacy, Faculty of Medical Sciences, University of Kragujevac, Svetozara Markovića.
Journal of clinical psychopharmacology
|September 29, 2025
概括
抗生素诱导的躁狂,称为抗生素痴迷,可以被克拉里胺激发. 这种罕见的副作用,以情绪变化和过度活跃为特征,通常在停止服用抗生素后消失.
科学领域:
- 药物监督 药物监督 药物监督
- 神经精神病学是一种神经精神病学.
- 药物不良反应 药物不良反应
背景情况:
- 抗生素痴迷是一种罕见的不良反应,其特征是抗生素诱导的躁狂.
- 克拉里思罗米经常与抗生素痴迷有关.
- 症状包括情绪升高,过度活跃和幻觉,通常在停药后得到解决.
研究的目的:
- 系统地审查报告的抗生素痴迷病例.
- 为了描述克拉里胺诱导的躁狂的临床模式.
- 为指导临床识别和管理这种不良反应.
主要方法:
- 按照PRISMA指南进行系统审查.
- 在主要数据库 (PubMed,科学网,Scopus,EMBASE) 中搜索克拉里斯罗米辛和躁狂相关术语.
- 包括研究,无论语言或出版日期;数据提取人口统计,呈现,治疗和因果关系.
- 查询FAERS和EudraVigilance对自发报告的精神病不良事件的情况.
主要成果:
- 分析了32项涉及34名患者的研究.
- 躁狂发作发生在大约4天后开始清红素 (500毫克两次) 和持续了~3天.
- 精神病症状很常见;重复检查在5例中证实了因果关系.
- 鉴于因果关系的评估,克拉里斯罗米辛和躁狂之间可能存在关联.
结论:
- 克拉里思罗米辛可以导致二次躁狂,这是一个罕见的精神病副作用.
- 临床医生意识对于及时识别和适当管理至关重要.
- 及时识别和干预可以改善患者的治疗结果,并防止误诊.
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