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甘菌的抗瘤和免疫调节活性来自Ganoderma parvulum的多糖化合物

Katherin Contreras-Ramirez¹, Xiomara López-Legarda², Jorge H Tabares-Guevara³

¹Grupo de Investigaciones Biomédicas UniRemington, Facultad de Ciencias de la Salud, Corporación Universitaria Remington, Medellín, Colombia.

Bioscience reports

|September 29, 2025

概括

甘菌的多糖体通过刺激免疫系统,表现出抗瘤的作用. 这些化合物在没有毒性的情况下抑制了淋巴瘤和瘤细胞的生长,这表明了作为免疫疗法的潜力.

科学领域:

免疫学免疫学免疫学
药理学药理学是指药理学的学科.
菌类学菌类学是指菌类学.

背景情况:

多糖因其抗瘤和免疫调节潜力而闻名.
菌多糖活性受到提取方法,菌来源和分子量的影响.

研究的目的:

研究来自Ganoderma parvulum (GP) 的多糖的抗瘤和免疫调节作用.

主要方法:

在抑制小鼠淋巴瘤中评估GP粗聚糖.
在实验室中对外聚糖 (GEPS) 和内聚糖 (GIPS) 对瘤细胞增殖和免疫标记物的评估.

主要成果:

GP原始多糖体表现出抗淋巴瘤活性,没有细胞毒性.
GEPS和GIPS抑制了瘤细胞的扩散.
GEPS和GIPS通过增加氧化,TNF-α,MCP-1,IL-1β,IL-18和Caspase-1来调节免疫反应,同时降低NLRP3,IL-10和IL-6的调节.

结论:

来自GP的多糖体具有抗瘤特性.
抗瘤机制涉及主体免疫系统的激活,特别是通过巨细胞刺激.

关键词:

它具有抗瘤活性.癌症免疫疗法免疫疗法菌类的多糖类是真菌的多糖类.巨细胞是什么?巨细胞是什么?的β-葡萄糖.

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