在糖尿病预防计划中,BMI与认知表现的关联 研究结果 研究结果
José A Luchsinger1, Qing Pan2, William C Knowler2
1Department of Medicine and Epidemiology, Columbia University Irving Medical Center, New York, New York, USA.
Obesity (Silver Spring, Md.)
|September 29, 2025
概括
超重或肥胖以及糖尿病或糖尿病前期患者的口头学习和记忆能力下降的速度较慢,与正常BMI患者相比. 这表明,更高的BMI对这一群体的认知功能有潜在的保护作用.
科学领域:
- 内分泌学 在内分泌学.
- 神经科学是一个神经科学.
- 公共卫生 公共卫生
背景情况:
- 糖尿病和糖尿病前期与认知能力下降有关.
- 体重指数 (BMI) 是代谢健康的一个关键因素.
- 了解这些人群中的BMI和认知之间的相互作用对于公共卫生干预至关重要.
研究的目的:
- 研究身体质量指数 (BMI) 类别与认知表现之间的关联.
- 基于BMI,分析糖尿病或糖尿病前期患者随时间推移的认知轨迹.
- 为了确定超重或肥胖是否会影响认知能力下降的速度.
主要方法:
- 利用了来自糖尿病预防计划结果研究 (DPPOS) 的数据.
- 分类参与者的BMI为正常,超重和肥胖.
- 使用简要的西班牙语英语口语学习测试 (B-SEVLT) 和数字符号替换测试 (DSST) 评估认知功能,使用线性混合模型分析15年的变化.
主要成果:
- 8年超重或肥胖与语言学习和记忆能力的较慢下降有关 (B-SEVLT回忆).
- 超重或肥胖的参与者在15年表现出更高的修改型迷你心理状态考试 (3MS) 成绩.
- 总共分析了2285名参与者,在第8年31%的超重和60%的肥胖者.
结论:
- 超重和肥胖与糖尿病或糖尿病前期患者的口头学习和记忆力下降有关.
- 在特定人群中,较高的BMI可能会对认知能力下降产生保护作用.
- 研究结果表明,在代谢性疾病背景下,BMI和认知健康之间存在复杂的关系.
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