身体圆度指数与心脏代谢多病症和死亡率相关:一个多州模型
Xi Cai1, Yicheng Liao2, Xuemei Yang3
1Department of Rheumatology and Immunology, Kailuan General Hospital, North China University of Science and Technology, Tangshan, Hebei, China.
Obesity (Silver Spring, Md.)
|September 29, 2025
概括
身体圆度指数 (BRI) 是心脏代谢疾病 (CMD) 和多病症 (CMM) 风险的关键指标. 较高的BRI水平预测CMM和死亡率的风险增加,特别是在女性中,突出了针对性预防的需要.
科学领域:
- 心脏病学 心脏病学
- 代谢健康 代谢健康
- 公共卫生 公共卫生
背景情况:
- 心脏代谢性疾病 (CMD) 是全球健康的重大负担.
- 了解CMD和心脏代谢多病症 (CMM) 的新生物标志物对于早期干预至关重要.
- 身体圆度指数 (BRI) 已成为中心肥胖和代谢风险的潜在指标.
研究的目的:
- 研究身体圆度指数 (BRI) 与患心脏代谢疾病 (CMD),心脏代谢多病症 (CMM) 和全因死亡率的风险之间的关联.
- 评估BRI在CMM进展的不同阶段的影响.
- 探索一带一路协会中的性别特异和疾病特异差异.
主要方法:
- 一项前性队列研究,涉及Kailuan队列的87,902名参与者.
- 参与者被分为一带一路的四分之一.
- 考克斯的比例危险模型和多状态模型被用来评估风险和跨CMM阶段的过渡.
主要成果:
- 在13.68年的中位随访期内,BRI升高与第一个心脏代谢疾病 (FCMD),CMM和全因死亡率的风险增加有关.
- 多州分析显示,较高的BRI四分位数与从健康转变为FCMD和从FCMD转变为CMM的风险增加有关.
- BRI对死亡率的影响在CMM阶段不同,在CMM阶段观察到BRI最高四分位数的保护作用. 关联在女性中更强烈.
结论:
- 动态监测BRI作为一个有价值的生物标志物用于早期识别CMM风险和预后评估.
- 疾病和性别特定的预防策略是必要的,考虑到BRI的不同影响.
- BRI监测可以帮助对心脏代谢疾病的个性化风险分层.
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