超越范围:关于结肠癌查测试的最新情况
Timothy Yen1, Minh Do2, Swati G Patel2,3
1Division of Gastroenterology, Loma Linda University Health, Loma Linda, California.
结肠直肠癌 (CRC) 查对于预防死亡至关重要. 结肠镜检查和便检查被推作为平均风险个体的第一线选择.
科学领域:
- 胃肠病学 胃肠病学
- 在瘤学瘤学.
- 预防医学 预防医学
背景情况:
- 结肠直肠癌 (CRC) 发病率在年轻人中正在增加.
- 查吸收率仍然低于最佳水平,特别是在45-49岁年龄组.
- 通过查早期检测可以预防CRC的死亡率.
研究的目的:
- 审查平均风险CRC查选项.
- 为选择CRC查测试提供一个框架.
- 讨论既有和新的查方式.
主要方法:
- 关于CRC查试验的文献综述.
- 测试特征的分析:灵敏度,可访问性,成本和设置适当性.
- 组织与机会查方法的比较.
主要成果:
- 最佳的CRC查测试对先进的癌前结直肠病变 (APL) 和早期CRC敏感.
- 已建立的测试包括便免疫化学测试,多目标便DNA和结肠镜检查.
- 新的测试包括基于便的RNA,下一代便DNA和基于血液的DNA测试.
- 基于血液的测试显示对APL的敏感性较低,可能阻碍预防.
结论:
- 试验吸收,成本和疗效指南 CRC查方式选择.
- 结肠镜检查和便检查通常被推作为第一线CRC查选择.
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