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Updated: Aug 1, 2026

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对IL-10RAR104W/R104W鼠标模型的生成和表型分析

Xiaoya Cao1,2, Zhiyang Zeng3,4,2, Xiya Cao4

  • 1Department of General Surgery, South Campus of Sixth People's Hospital, Shanghai Jiaotong University, Shanghai 201499, China.

Inflammatory bowel diseases
|September 29, 2025
PubMed
概括

一种具有IL-10RA突变的新小鼠模型发展出结肠炎,为早期发病的炎症性肠病 (VEO-IBD) 和潜在的治疗策略提供了洞察力.

关键词:
这就是CRISPR/Cas9的作用.在IL-10RA中使用.人性化的小鼠模型非常早期发病的炎症性肠病.

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相关概念视频

Mouse Models of Cancer Study02:43

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...