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与月经周期阶段和月经前失调障碍相关的白质区域体积

Elin Stenhammar¹, Manon Dubol¹, Louise Stiernman²

¹Department of Women's and Children's Health, SciLifeLab, Uppsala University, Uppsala, Sweden.

Biological psychiatry global open science

|September 29, 2025

概括

患有 premenstrual dysphoric disorder (PMDD) 的女性的白质量 (WMVs) 比对照组更大. 这些大脑差异似乎是一种特征,而不是一种状态,表明PMDD的潜在生物标志物.

科学领域:

神经科学是一个神经科学.
精神病学是一个精神病学.
神经成像是一种神经成像.

背景情况:

月经前失调障碍 (PMDD) 是一种与激素相关的精神障碍.
有证据表明,白质结构在黄质阶段发生PMDD的变化.
这项研究调查了PMDD妇女在整个月经周期中的白质量 (WMVs).

研究的目的:

为了比较PMDD女性的WMV与整个月经周期的对照女性.
为了确定观察到的WMV差异是否是状态或特征类特征.
确定与PMDD相关的潜在结构性大脑标记物.

主要方法:

在28名患有PMDD的女性和27名对照女性中使用了解剖MRI.
扫描是在毛囊中期和晚期黄质阶段进行的.
基于voxel的形态测量 (ROI和全脑) 评估了WMVs.

主要成果:

在WMV上没有发现按阶段分组的相互作用效应.
患有PMDD的女性在整个周期阶段显示出比对照组更多的WMV.
在特定的白质通道 (例如,未切割的囊) 和大脑区域 (例如,尾区域) 观察到WMV的增加.

结论:

患有PMDD的女性比对照组显示出更大的WMV,而不管月经周期的阶段.
这些发现表明WMV差异是PMDD的特征性标记物.
改变的WMV涉及至关重要的情绪处理,记忆和情绪调节的路径.

关键词:

月经周期月经周期.心理健康心理健康经前失调性失调性障碍经前失调性失调性障碍基于voxel的形态测量方法白质是白质的组成部分.

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