肺癌生存率和死亡率的预测因素:喀拉拉邦的一项多中心研究
Nisha Jose1, Manuprasad Avaronnan2, Narayanankutty Warrier3
1Department of Community Medicine, Achutha Menon Centre for Health Sciences Studies, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum, Kerala, India.
概括
印度的肺癌生存率很差,死亡率很高. 淋巴结状况显著影响肺癌死亡风险,突出需要更好的风险分层.
科学领域:
- 在瘤学瘤学.
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 肺癌在印度是一个重大的健康问题,导致癌症发病率和死亡率.
- 由于随访挑战,印度肺癌患者的生存分析数据有限.
- 这项研究解决了了解印度肺癌存活率和死亡率因素的需要.
研究的目的:
- 调查印度肺癌患者的生存率.
- 为了确定与肺癌死亡率相关的因素.
- 为公共卫生政策和临床风险分层提供信息.
主要方法:
- 一项基于医院的注册研究,涉及印度喀拉拉邦六家三级医院的761名原发性肺癌患者.
- 患者在诊断后被跟踪了两年.
- 招募了病理证明的原发性肺癌病例 (ICD-11代码C33和C36).
主要成果:
- 平均存活时间为8.6个月,累积死亡率为6个月后39.9%,1年后57.8%,2年后70.2%.
- 较高的死亡风险与晚期淋巴结状况相关:N2 (HR=4.9),N3 (HR=5.9) 和NX (HR=31.7) 与N1.1.相比.
- 总体死亡率为每100个人/月6.38.
结论:
- 这些发现强调了淋巴结状况在预测肺癌死亡率方面的关键作用,超越了吸烟史.
- 结果为风险分层提供了关键数据,并为癌症诊断和治疗的公共卫生政策提供了信息.
- 有效地识别和评估死亡率预测因素对于改善患者的治疗结果至关重要.
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