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向kynureninase通过MAPK信号抑制减轻辐射诱导的肠道损伤

Qingxie Liu¹, Zhi Ling^1,2, Yue Zhu³

¹Department of Gastroenterology, Yangzhou Key Laboratory for Precision Treatment of Refractory Bowel Diseases, Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou 225001, China.

Mediators of inflammation

|September 29, 2025

概括

在辐射引起的肠损伤中,Kynureninase (KYNU) 的调高. 抑制KYNU可以通过减少炎症和促进细胞存活来保护肠道免受损伤.

科学领域:

生物化学生化学
分子生物学分子生物学
胃肠病学胃肠病学

背景情况:

京氨酶 (KYNU) 在酸盐代谢和免疫调节中至关重要.
它在辐射引起的肠损伤 (RIII) 中的作用尚不清楚.

研究的目的:

调查KYNU在RIII病原发生中的作用.
评估KYNU抑制作为RIII的治疗策略.

主要方法:

在小鼠中进行转录基因分析和实验验证.
在体外研究中使用NCM460细胞与KYNU敲击.
RNA测序和途径分析.
在体外和体内,用卡比多巴 (CBP) 制止KYNU的药理抑制.

主要成果:

在RIII结肠组织中,KYNU表达显著上调.
在肠道细胞中,KYNU敲击减弱了辐射诱导的亡和氧化应激.
KYNU 沉默抑制了 MAPK 信号通路.
通过CBP治疗,可以防止辐射引起的肠上皮损伤,并改善肠道屏障功能.

结论:

在RIII发展中,KYNU发挥着关键作用.
抑制KYNU通过调节MAPK信号提供了对肠道损伤的保护.
准KYNU为RIII提供了一个潜在的治疗方法.

关键词:

在 MAPK 信号通道中.卡比多帕是指一种碳酸盐.基因氨酸酶 (KYN) 是一种辐射引起的肠道损伤

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