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在乳腺癌发育过程中,FGFR2表达与亚型特定的瘤微环境 (TIME) 相关

Julia Sołek¹, Aleksandra Zielińska¹, Radzisław Kordek¹

¹Department of Pathology, Chair of Oncology, Medical University of Lodz, Lodz, Poland.

Frontiers in oncology

|September 29, 2025

概括

纤维细胞生长因子受体2 (FGFR2) 在光线A乳腺癌与免疫抑制标志物相关. 这表明FGFR2和雌激素受体信号可能会在这些特定的乳腺癌亚型中驱动免疫逃避和瘤进展.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
癌症研究癌症研究

背景情况:

纤维细胞生长因子受体2 (FGFR2) 是光线乳腺癌 (BCa) 的关键驱动因素.
已知FGFR2在内分泌抵抗中的作用,但其对瘤免疫微环境 (TIME) 的影响,特别是乳腺癌从直位管道癌 (DCIS) 到侵入性管道癌 (IDC) 的进展期间,尚不清楚.

研究的目的:

调查FGFR2表达和BCa进展期间免疫细胞透之间的关联.
探索不同BCa亚型的FGFR2和免疫标记物之间的关系,重点关注光线A瘤.

主要方法:

用FGFR2和免疫标记物 (CD8,CD68,CD163,FOXP3) 的免疫组织化学方法对99个BCa标本进行了回顾性分析.
疾病不同阶段 (DCIS与IDC) 和BCa亚型的免疫细胞密度的比较.
统计分析FGFR2表达和免疫标志物之间的相关性.

主要成果:

从DCIS到IDC的进展显示CD8+T细胞和CD68+巨细胞的透增加.
FGFR2表达与CD8+,CD163+和FOXP3+细胞密度正相关,特别是在具有广泛DCIS成分的瘤中.
这些相关性是特定于光线A瘤的,在非光线亚型中没有发现显著的关联.

结论:

在光线ABCa中的FGFR2表达与免疫抑制时间相关,由增加的CD163+巨细胞和FOXP3+T细胞表明.
FGFR2和雌激素受体信号传递可能会协同作用,促进免疫逃避和瘤进展在光线ABCa.
这些发现突出了亚型特异性相互作用,并要求进一步调查FGFR2在BCa免疫逃避中的作用,尽管由于小子组大小存在局限性.

关键词:

在FGFR2中.乳腺癌乳腺癌乳腺癌在位置上的管道癌.纤维细胞生长因子受体侵袭性乳腺癌是一种侵袭性乳腺癌.瘤免疫系统的环境与瘤相关的巨细胞.透到瘤中的淋巴细胞

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