脑动脉瘤手术后患者高压氧疗法的有效性:系统性审查和元分析
Yue Gao1, Xiaoyuan Sun2, Guozhong Wang1
1Department of Hyperbaric Oxygen, Civil Aviation General Hospital, Beijing, China.
Frontiers in neurology
|September 29, 2025
概括
高压氧气疗法 (HBOT) 在内动脉瘤手术后显著改善神经恢复和功能独立性. 这种辅助治疗改善了结果和生活质量,支持其临床使用.
科学领域:
- 神经外科 神经外科
- 高压医学高压医学
- 临床结果研究研究
背景情况:
- 内动脉瘤的手术治疗往往导致术后的神经缺陷和生活质量的降低.
- 高压氧气疗法 (HBOT) 作为改善神经恢复和功能结果的辅助药物被探索,但其有效性仍在争论中.
研究的目的:
- 系统地审查和分析HBOT在改善临床结果,神经改善,功能独立和脑内动脉瘤手术后患者的生活质量的有效性.
主要方法:
- 随机对照试验 (RCT) 的系统审查和元分析,比较HBOT加常规护理与仅常规护理.
- 搜索了包括PubMed,Web of Science,CNKI,万芳和VIP在内的数据库,截至2025年4月.
- 使用固定或随机效应模型分析数据,计算风险比率 (RR) 和标准化平均差异 (SMD) 以95%的置信区间 (CI).
主要成果:
- 分析了11个涉及2,268名患者的RCT.
- HBOT显著改善了临床治疗疗效 (RR=1.19) 和神经功能 (SMD=-0.63).
- 在功能独立方面观察到明显的改善,包括日常生活活动 (ADL;SMD=1.24),巴特尔指数 (SMD=1.00) 和SF-36分数 (SMD=1.32),具有最小的异质性 (I2=0%).
结论:
- 辅助HBOT显著提高神经恢复,功能结果,并在内动脉瘤手术后的生活质量.
- 这些发现支持对这一患者群体进行HBOT的临床采用.
- 建议进一步进行高质量的多中心研究,以确认长期影响.
相关概念视频
Aneurysm IV: Nursing Management
380
Vigilant monitoring for aneurysm rupture is essential for patients undergoing aortic surgery.Preoperative Nursing ManagementContinuously monitor the patient for manifestations of aneurysm rupture, such as pallor, weakness, tachycardia, hypotension, abdominal, back, groin, or periumbilical pain, changes in consciousness, and a pulsating abdominal mass. Regularly assess the patient's peripheral pulses.Instruct the patient to consume a clear liquid diet the day before surgery and administer...
380
Aneurysm III: Interprofessional Care
255
Aneurysm management involves either conservative medical therapy or surgical intervention, depending on the size and symptoms of the aneurysm. Conservative management is generally reserved for smaller, asymptomatic aneurysms, while larger or symptomatic aneurysms often necessitate surgical repair.Conservative Medical TherapyFor small, asymptomatic aneurysms, particularly abdominal aortic aneurysms (AAA) less than 5.5 centimeters in diameter, conservative medical therapy is recommended. This...
255
Treatment for Pulmonary Arterial Hypertension: Oxygen Therapy for Respiratory Failure
589
Oxygen therapy has emerged as a significant tool in enhancing the quality of life for patients suffering from pulmonary arterial hypertension (PAH). While this therapy has principally been studied on patients with significant hypoxemia, this therapeutic approach helps prevent potential organ damage and can be administered in the comfort of one's home.
Oxygen therapy is vital in increasing and maintaining blood oxygen levels in PAH patients. As a result, it aids in reducing fatigue,...
Oxygen therapy is vital in increasing and maintaining blood oxygen levels in PAH patients. As a result, it aids in reducing fatigue,...
589
Aneurysm II: Clinical Manifestations and Diagnostic Studies
299
Thoracic, aortic arch and abdominal aneurysms are significant vascular conditions that can present with various clinical manifestations and lead to serious complications. Understanding these manifestations and the appropriate diagnostic studies is essential for effective management and treatment.Thoracic Aortic AneurysmsThoracic aortic aneurysms often remain asymptomatic until they reach a size that impinges on adjacent structures. They typically cause deep, diffuse chest pain that radiates to...
299


