硬币的两面:EPAS-1作为肺栓塞评估中的潜在D-dimer替代品
Abdullah Icli1, Ahmet Taha Sahin2, Yakup Alsancak1
1Department of Cardiology, Necmettin Erbakan University, Faculty of Medicine.
Acta Cardiologica Sinica
|September 29, 2025
概括
在肺栓塞 (PE) 患者中,内皮PAS域蛋白-1 (EPAS-1) 水平升高,与疾病严重程度相关. 随着治疗,EPAS-1的水平下降,这表明它作为PE的诊断和预后生物标志物的潜力.
科学领域:
- 心脏病学 心脏病学
- 肺部医学 肺部医学
- 生物标志物研究 生物标志物研究
背景情况:
- 肺血栓塞栓症 (PE) 的诊断和严重程度评估依赖于各种临床和实验室参数.
- 内皮PAS域蛋白-1 (EPAS-1),一种低氧诱导因子,是潜在的生物标志物,用于涉及低氧的条件.
研究的目的:
- 研究PE患者在诊断时和治疗后EPAS-1水平的变化.
- 评估EPAS-1水平与已建立的PE评分系统和实验室参数之间的相关性.
- 评估EPAS-1作为PE的潜在诊断和预后标志物.
主要方法:
- 研究了一组60名PE患者和60名对照组.
- 在入院时测量了EPAS-1水平,实验室参数和PE风险/严重性得分 (包括PESI).
- 治疗后3天重新评估EPAS-1水平,以评估治疗反应.
主要成果:
- 与对照组相比,PE患者的EPAS-1水平显著更高 (p < 0.001).
- EPAS-1水平与PE严重性指数 (PESI) 得分呈正相关性.
- 治疗后EPAS-1水平下降,根据治疗类型的不同趋势. 在非幸存者中,尽管接受治疗,EPAS-1水平仍然增加 (p = 0.014).
结论:
- 在PE中,EPAS-1水平升高,与疾病严重程度得分相关.
- EPAS-1 作为PE诊断的宝贵生物标志物,可以帮助评估治疗疗效.
- 在对PE患者的综合评估中,EPAS-1可能发挥补充作用.
相关概念视频
01:29Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care
328
Diagnosing Pulmonary EmbolismDiagnosing pulmonary embolism (PE) involves clinical assessment and advanced imaging tests. The preferred diagnostic tool is the spiral (helical) CT scan or CT angiography (CTA), which uses intravenous contrast media to visualize the pulmonary vasculature and identify emboli.A ventilation-perfusion (V/Q) scan is an alternative for patients unable to receive contrast media. This scan includes both perfusion and ventilation scanning. Perfusion scanning involves...
328
01:29Pulmonary Embolism I: Introduction
516
Pulmonary embolism (PE) occurs when a thrombus, fat or air embolus, amniotic fluid, or tumor tissue blocks one or more pulmonary arteries. These blockages originate in the venous system or the right side of the heart.EtiologyPE primarily arises from deep vein thrombosis (DVT) and other hypercoagulable states, such as inherited thrombophilias. Additional etiological factors include venous stasis, commonly seen in obesity, and endothelial injury from surgery and trauma. Less common causes include...
516
01:27Pulmonary Embolism III: Nursing Management
363
A pulmonary embolism occurs when a thrombus, amniotic fluid, tumor tissue, fat, or air embolus blocks one or more pulmonary arteries. Effective nursing management and patient education are crucial for improving outcomes and preventing recurrence.Nursing management starts with obtaining a comprehensive patient history, particularly noting any history of deep vein thrombosis (DVT). Assess for clinical manifestations, including dyspnea, chest pain, crackles, heart murmurs, and signs of right-sided...
363
01:18Effects of EDTA on End-Point Detection Methods
621
Different methods, such as visual observance of metal-ion indicators, spectroscopic techniques, and potentiometric methods, can determine the endpoint of an EDTA titration.
In the visual method, metal-ion indicators (metallochromic dyes), which have distinct colors in their free and complex forms, are added to the mixture to signal the titration's end point. They form stable complexes with metal ions, but these complexes are weaker than the corresponding metal–EDTA complexes. As a...
In the visual method, metal-ion indicators (metallochromic dyes), which have distinct colors in their free and complex forms, are added to the mixture to signal the titration's end point. They form stable complexes with metal ions, but these complexes are weaker than the corresponding metal–EDTA complexes. As a...
621