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艾滋病毒风险评估工具的诊断性能,用于识别暴露前预防候选人:系统性审查和元分析
Myo Minn Oo1,2, Monica Rudd1,2, Caley Shukalek3
1Division of Infectious Diseases, St. Michael's Hospital, Toronto, ON, Canada.
EClinicalMedicine
|September 29, 2025
概括
经过验证的艾滋病毒风险评估工具可以帮助某些群体实施PrEP. 然而,需要改进的工具来实现平等的获取,特别是非洲以外的 cisgender 女性.
科学领域:
- 流行病学 流行病学
- 公共卫生 公共卫生
- 诊断的准确性 诊断的准确性
背景情况:
- 实施艾滋病毒暴露前预防 (PrEP) 需要有效的艾滋病毒风险评估.
- 系统性审查和元分析,以评估艾滋病毒风险评估工具的诊断性能.
研究的目的:
- 评估现有的艾滋病毒风险评估工具的诊断准确性.
- 识别用于公平获得PrEP的工具可用性的差距.
主要方法:
- 观察性研究的系统审查 (1998-2024) 来自MEDLINE,Embase,CINAHL.
- 超分析计算诊断性能曲线下的聚合面积 (pAUC).
- 在各种截止点对灵敏度和特异性的分析.
主要成果:
- 27项研究评估了各种人群中的15种工具.
- 在与男性发生性关系 (MSM) 的男性中,SexPro表现最高 (pAUC:0.75).
- 非洲以外的cisgender女性的工具缺乏;VOICE (pAUC:0.65) 在非洲得到了验证.
结论:
- 经过验证的工具有助于在特定人群中识别艾滋病毒风险.
- 迫切需要工具来确保公平的PrEP接入服务不足的群体,包括全球的 cisgender 女性.
- 整合本地数据对于提高工具相关性和有效性至关重要.
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