在COVID-19流行病之前,期间和之后的流行性呼吸道病毒循环和测试的变化
Kim El-Haddad1, Wei Liu2, Patrick Burke3
1Department of Pediatrics, Center for Pediatric Infectious Disease, Cleveland Clinic Children's, Cleveland, Ohio, USA.
Open forum infectious diseases
|September 29, 2025
概括
随着COVID-19大流行,流行性呼吸道病毒的循环中断,不成比例地影响了像A型流感和RSV这样的冬季病毒. 春季和全年病毒的恢复速度更快,为未来的流行病准备提供了见解.
科学领域:
- 病毒学 病毒学
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- SARS-CoV-2 流行病和相关措施显著改变了流行性呼吸道病毒的循环模式.
- 虽然许多病毒在流行后急剧下降,但它们的恢复有所不同,受到与SARS-CoV-2的循环重叠的影响.
研究的目的:
- 调查SARS-CoV-2流行病对特有呼吸道病毒的循环动态的影响.
- 确定血液循环与SARS-CoV-2的重叠如何影响病毒的移位和恢复到大流行前的模式.
主要方法:
- 从2015年到2024年5月对6种呼吸道病毒进行鼻样本测试数据的分析.
- 利用中断时间序列,波形和中位数回归分析来比较疫情前和后SARS-CoV-2出现趋势的阳性和峰值位移.
主要成果:
- 冬季病毒 (流感A,RSV) 呈现显著下降和长期复苏,观察到季节性变化.
- 春季病毒 (人体肺炎病毒,类流感病毒3) 和全年病毒 (腺病毒,鼻病毒/肠病毒) 显示出弹性,迅速恢复到大流行前的阳性水平.
- 与春季病毒相比,冬季病毒在季节性时间表中经历了更明显的转变.
结论:
- COVID-19大流行不成比例地影响了冬季占主导地位的呼吸道病毒,延迟了它们的恢复.
- 春季和全年病毒显示较轻微的偏差,并更快地正常化.
- 这些发现为加强未来的流行病准备战略提供了关键的见解.
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