抗生素在患有无症状细菌性尿症的移植患者中的有效性和安全性:随机对照试验的系统审查和元分析
Abdullah Tarik Aslan1, Lokman Hekim Tanriverdi2, Adrian V Hernandez3,4
1Faculty of Medicine, UQ Centre for Clinical Research, University of Queensland, Brisbane, Queensland, Australia.
Open forum infectious diseases
|September 29, 2025
概括
在移植接受者中,针对无症状细菌尿的常规抗生素治疗不会改善结果,可能会增加风险. 目前的证据表明,在KTRs中避免对这种情况进行系统的查和治疗.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 移植医学 移植医学
- 传染性疾病 传染性疾病
背景情况:
- 无症状细菌性尿病 (ASB) 通常在移植接受者 (KTRs) 中进行查和治疗.
- 在KTR中治疗ASB的抗生素治疗的有效性和安全性仍在调查中.
研究的目的:
- 评估抗生素治疗在KTRs中ASB管理中的作用和影响.
- 综合来自随机对照试验的证据,用于对移植患者的ASB管理.
主要方法:
- 随机对照试验 (RCT) 的系统文献搜索到2023年5月.
- 用逆方差随机效应模型和Mantle-Haenszel方法对罕见结果进行元分析.
- 使用ROB-2标准进行偏差风险评估.
主要成果:
- 分析了四项涉及478名参与者的RCT.
- 抗生素治疗没有显著增加或降低急性肌炎,症状性尿路感染,死亡率,移植损失或排斥的风险.
- 在抗生素和无治疗组之间,没有观察到副作用或血清肌水平的显著差异.
结论:
- 目前的证据不支持在KTRs中进行ASB的常规查和抗生素治疗.
- 对移植患者的ASB抗生素干预缺乏证明的益处,并带有潜在的风险.
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