艾滋病毒和/或慢性C型肝炎患者的摄入量和骨矿物质密度
Zoey B Temesgen1, Zelalem Temesgen2, Roger J Bedimo3
1University of Minnesota Medical School, Minneapolis, Minnesota, USA.
饮食中的摄入量与患有型肝炎病毒 (HCV) 感染的男性的骨矿物质密度 (BMD) 较低有关. 在患有人类免疫缺陷病毒 (HIV) 或HIV/HCV共感染的人群中没有发现显著的关联.
科学领域:
- 骨健康研究 骨健康研究
- 传染病对骨密度的影响
- 营养流行病学 营养流行病学
背景情况:
- 骨矿物质密度降低 (BMD) 常见于患有人类免疫缺陷病毒 (HIV),C型肝炎病毒 (HCV) 或两者兼有的个体.
- 对于这些患者群体来说,了解在骨健康中的作用至关重要.
研究的目的:
- 调查艾滋病毒,HCV或艾滋病毒/HCV共感染患者的饮食摄入量和骨质量之间的关联.
- 为了在不同感染状态和对照组中比较BMD和摄入量.
主要方法:
- 招募了452名病毒学上抑制的HIV,未经治疗的HCV,HIV/HCV共感染或没有感染的男性.
- 通过Hertzler-Frary问卷和BMD通过双能X射线吸收计评估饮食中的摄入量.
- 采用了统计分析,包括千二测试,共变量分析和斯皮尔曼相关性,调整为共变量.
主要成果:
- 骨质疏松症和骨质疏松症很普遍,但没有观察到感染组和骨质疏松症之间的显著关联.
- 饮食中较低的摄入量和骨质疏松症之间的统计学显著相关性仅在HCV单一感染的患者中发现.
结论:
- 饮食中的摄入量仅在HCV单一感染患者的亚组中与减少的BMD有相关性.
- 这些发现突出了与HCV感染个体骨密度缺陷的特定营养联系.
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