在新鲜胚胎移植周期中,季节和妊娠结果之间的关联:系统性审查和元分析

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Qiang Deng¹, Fengying Wu¹, Jun Wang¹

¹Hubei University of Chinese Medicine, Wuhan, China.

Frontiers in public health

|September 29, 2025

概括

这次审查没有发现新鲜胚胎转移周期中季节和怀孕成功之间的显著联系. 然而,特定的气候显示出差异,这表明需要进一步的研究.

科学领域:

生殖医学生殖医学
公共卫生公共卫生
环境医学环境医学

背景情况:

不孕症是一个重要的全球健康问题,需要对辅助生殖技术 (ART) 的可修改因素进行研究.
季节性变化与自然受孕和怀孕结果有关,但它们对ART,特别是新鲜胚胎移植的影响仍在争论中.
了解季节性影响可以为ART治疗计划提供信息,并优化成功率.

研究的目的:

研究在接受新鲜胚胎移植周期的妇女中季节性暴露和怀孕结果之间的关联.
提供基于证据的指导,以确定季节性时间是否应成为ART治疗计划中的一个因素.
为了澄清季节和ART成功之间的有争议的关系.

主要方法:

一个系统的审查和元分析,遵循PRISMA指南.
在七个数据库中进行文献搜索,使用固定效应模型进行数据合成.
基于科本气候分类和偏差风险评估的子组分析,使用纽卡斯尔-太华尺度.

主要成果:

分析了包括159,696个新鲜胚胎移植周期在内的19项回顾性研究.
在季节性和临床妊娠或活产率之间没有发现总体显著的关联.
观察到特定于气候的变化:与其他季节相比,夏季 (Cwa气候) 和春季 (Dfb气候) 的活产率更高.

结论:

季节性变化不会显著影响新鲜胚胎移植周期中的妊娠结果.
观察到的气候特异性差异需要进一步调查多因素影响.
临床医生和患者可以专注于医疗因素而不是季节性时间来规划ART.

关键词:

胚胎转移是通过胚胎转移进行的.在体外受精的受精.新鲜胚胎转移周期这是一个元分析.季节的季节季节的季节

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