在有或没有家族病史的患者中比较冠状动脉疾病的发生率
Ramin Khameneh Bagheri1, Hosna Hosseini Moghaddam2, Mostafa Ahmadi1
1Interventional Cardiologist, Department of Cardiovascular Diseases, Faculty of Medicine, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran.
American heart journal plus : cardiology research and practice
|September 29, 2025
概括
阳性家族病史 (FH) 与伊朗患者更严重的冠状动脉疾病 (CAD) 有关. 了解FH可以帮助识别有针对性预防和治疗策略的高风险个体.
科学领域:
- 心脏病学 心脏病学
- 遗传学 遗传学 是一个
- 公共卫生 公共卫生
背景情况:
- 家庭病史 (FH) 和遗传因素是冠状动脉疾病 (CAD) 风险的重要贡献者.
- 关于伊朗人口中FH和CAD模式之间的关联存在有限的数据.
研究的目的:
- 评估伊朗患者的CAD参与模式,无论是否具有阳性FH.
- 确定区分这些群体的风险因素.
主要方法:
- 一项涉及2019年4月至2020年4月在伊朗马什哈德确认CAD的300名患者的横截面研究.
- 根据CAD的FH,患者被分为两组.
- 使用多变量逻辑回归来评估风险因素.
主要成果:
- 170名患者呈FH阳性,而130名患者没有.
- 年龄,男性性别和高血压是FH组之间的显著差异化因素.
- 阳性FH独立地与更广泛和更严重的CAD相关,包括多血管参与.
结论:
- 阳性FH与伊朗患者的CAD严重程度和程度的增加密切相关.
- 将FH纳入风险分层可以提高高风险个体的识别.
- 这可以导致更有针对性的CAD预防和治疗策略.
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