用原生素微粒制备的黄素纳米囊具有降低偏醇诱导的氧化应激的潜力
Ankita Hooda1, Bimlesh Mann2, Abhishek Dutt Tripathi1
1Department of Dairy Science and Food Technology Bananas Hindu University Varanasi India.
Food science & nutrition
|September 29, 2025
概括
在素小粒中纳米封装的黄素显示出抗氧化作用,保护小鼠免受偏醇诱导的肝脏和脏毒性. 这增强了库尔库明的作用.
科学领域:
- 生物化学 生化学
- 药理学 药理学是指药理学的学科.
- 纳米技术 纳米技术
背景情况:
- 过量服用黄醇可以导致严重的肝脏毒性.
- 黄素具有已知的抗氧化特性.
- 原生素 (CN) 粒细胞可以封装黄素纳米颗粒 (NE).
研究的目的:
- 为了验证黄素纳米封装 (NE) 在原生素 (CN) 微粒中的保护性抗氧化作用.
- 在小型动物模型中评估NE曲素在减轻类醇诱导的肝脏毒性方面的疗效.
- 为了证明CN小粒在黄素输送和生物可用性方面的保护作用.
主要方法:
- 雄性白色老鼠接受了NE或原始的黄素口服4天.
- (P) 被口服以诱导毒性.
- 生物化学标记物 (BUN,肌素,肝酶) 和抗氧化剂指数 (catalase,GPx,SOD,LPO) 在肝脏同质物中进行测量.
- 建立了六个实验组,包括预防和治疗治疗,以及对照组.
主要成果:
- NE黄素治疗降低了氨酸,谷氨酸酸胺转氨酶和性酸酶的水平.
- 抗氧化酶活动 (catalase,GPx,SOD) 增加,而脂质过氧化 (TBARS) 在与仅服用青的小鼠相比,在接受NE青治疗的小鼠中减少.
- 血尿素 (BUN) 水平在接受NE粉末治疗的群体中相对降醇组的增加.
结论:
- 在素微粒中纳米封装的黄素显示出显著的抗氧化和保护作用,对抗类醇诱导的肝脏毒性.
- 素微粒增强了黄素作为抗氧化剂的生物可用性和治疗潜力.
- 这项研究证实了NE黄素的使用作为一种有前途的治疗策略,用于控制药物诱导的器官毒性.
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