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复星通过抑制p38 MAPK信号通路来改善睡眠不足小鼠的认知功能

Yijie Tang¹, Xiyuan Xie¹, Haixing Wu¹

¹Department of Anesthesiology, Fuzhou University Affiliated Provincial Hospital, School of Medicine Fuzhou University Fuzhou Fujian China.

Food science & nutrition

|September 29, 2025

概括

复星 (Resveratrol,简称RES) 有效地改善了小鼠睡眠不足引起的认知缺陷和海马损伤. 这种天然化合物向MAPK通路,为饮食补充提供了潜在的可能性,以对抗与睡眠相关的认知问题.

科学领域:

神经科学是一个神经科学.
药理学药理学是指药理学的学科.
分子生物学分子生物学

背景情况:

睡眠不足 (SD) 与认知障碍和神经元损伤有关.
复星 (Resveratrol,简称RES) 是一种天然的多,具有已知的神经保护性.
了解RES对SD诱导的认知缺陷的影响至关重要.

研究的目的:

研究Resveratrol (RES) 在改善小鼠睡眠不足 (SD) 引起的认知缺陷方面的疗效.
探索RES在海马中的神经保护作用背后的分子机制.
确定睡眠障碍相关认知功能障碍的潜在治疗点.

主要方法:

成年雄性小鼠接受了72小时的睡眠剥夺 (SD),随后给予RES.
用莫里斯水迷宫,新型物体识别和开放现场测试来评估认知行为.
分析了海马体中的基因表达 (RNA测序),亡 (TUNEL) 和突触可塑性 (西方斑点,尼斯尔染色).

主要成果:

在SD小鼠中,RES的使用显著减轻了认知障碍.
RNA测序揭示了RES通过RES对基激活蛋白激酶 (MAPK) 途径的下调.
RES治疗改善了海马突触可塑性,并减少了SD引起的亡.

结论:

复星 (RES) 有效地逆转睡眠剥夺引起的认知功能障碍和海马损伤在小鼠.
RES的神经保护作用与MAPK信号通路的调制有关.
饮食补充RES显示有望预防或治疗与睡眠问题相关的认知问题.

关键词:

在 MAPK 信号通道中.认知功能保护保护认知功能在p38中,p38是什么?复星醇是一种复星醇.睡眠不足是因为睡眠不足.

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