Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Protein Folding01:25

Protein Folding

11.1K
Proteins are chains of amino acids linked together by peptide bonds. Upon synthesis, a protein folds into a three-dimensional conformation, critical to its biological function. Interactions between its constituent amino acids guide protein folding, and hence the protein structure is primarily dependent on its amino acid sequence.
Protein Structure Is Critical to Its Biological Function
Proteins perform a wide range of biological functions such as catalyzing chemical reactions, providing...
11.1K
Protein and Protein Structures02:15

Protein and Protein Structures

18.7K
18.7K
Globular and Fibrous Proteins02:21

Globular and Fibrous Proteins

5.2K
5.2K
Globular and Fibrous Proteins02:21

Globular and Fibrous Proteins

46.8K
Many proteins can be classified into two distinct subtypes - globular or fibrous. These two types differ in their shapes and solubilities.
Globular proteins are also known as spheroproteins and typically are approximately round in shape. They contain a mix of amino acid types and contain differing sequences in their primary structures. Globular proteins have many different functions, such as enzymes, cellular messengers, and molecular transporters. These roles often require the proteins to be...
46.8K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Why machine learning fails at mass spectrometry for small molecules.

Nature metabolism·2026
Same author

Reply to: Limited evidence of AI superiority in seasonal influenza vaccine strain selection.

Nature medicine·2026
Same author

AI-based methods for simulating, sampling, and predicting protein ensembles.

Current opinion in structural biology·2026
Same author

Protein FID: improved evaluation of protein structure generative models.

Bioinformatics (Oxford, England)·2026
Same author

Bridging the gap: aligning clinical decision support regulation with clinical practice in the era of artificial intelligence.

The Lancet. Digital health·2026
Same author

AssayMatch: Learning To Select Data for Molecular Activity Models.

Journal of chemical information and modeling·2026

相关实验视频

Updated: Jan 16, 2026

A Pipeline to Investigate the Structures and Signaling Pathways of Sphingosine 1-Phosphate Receptors
12:27

A Pipeline to Investigate the Structures and Signaling Pathways of Sphingosine 1-Phosphate Receptors

Published on: June 8, 2022

3.9K

普罗克塞尔基因:将蛋白质生成为3D密度

Felix Faltings, Hannes Stark, Regina Barzilay

    ArXiv
    |September 29, 2025
    PubMed
    概括

    我们介绍了ProxelGen,这是一种使用3D密度 (proxels) 而不是点云的新型蛋白质结构生成模型. 这种方法提高了蛋白质结构生成的新性和设计灵活性.

    科学领域:

    • 计算生物学是一种计算生物学.
    • 结构生物信息学 结构生物信息学
    • 人工智能在药物发现中的作用

    背景情况:

    • 目前的蛋白质结构生成模型主要使用3D点云表示.
    • 现有的生成模型的灵活性和条件能力存在局限性.

    研究的目的:

    • 开发ProxelGen,一种基于3D密度 (proxels) 的蛋白质结构的新生成模型.
    • 探索基于密度的表示对蛋白质生成任务的优点.
    • 为了在蛋白质设计中实现更灵活的形状调节.

    主要方法:

    • 开发了ProxelGen,这是一个运行在voxelized 3D密度 (proxels) 上的生成模型.
    • 使用基于3D卷积神经网络 (CNN) 的变异自编码器 (VAE).
    • 整合了一个在VAE的潜空间中运行的扩散模型.

    主要成果:

    • 与最先进的模型相比,ProxelGen样本显示出更高的新性和更好的FID分数.
    • 实现了与训练套件可比的可设计性.
    • 在一个图案脚手架基准中表现出卓越的性能.
    • 通过3D密度生成,在形状调节方面展示了增强的灵活性.

    更多相关视频

    Author Spotlight: Exploring Cellular Processes by Modeling Ligands in Cryo-EM Maps
    09:30

    Author Spotlight: Exploring Cellular Processes by Modeling Ligands in Cryo-EM Maps

    Published on: July 19, 2024

    2.0K
    Production, Crystallization and Structure Determination of C. difficile PPEP-1 via Microseeding and Zinc-SAD
    13:34

    Production, Crystallization and Structure Determination of C. difficile PPEP-1 via Microseeding and Zinc-SAD

    Published on: December 30, 2016

    11.9K

    相关实验视频

    Last Updated: Jan 16, 2026

    A Pipeline to Investigate the Structures and Signaling Pathways of Sphingosine 1-Phosphate Receptors
    12:27

    A Pipeline to Investigate the Structures and Signaling Pathways of Sphingosine 1-Phosphate Receptors

    Published on: June 8, 2022

    3.9K
    Author Spotlight: Exploring Cellular Processes by Modeling Ligands in Cryo-EM Maps
    09:30

    Author Spotlight: Exploring Cellular Processes by Modeling Ligands in Cryo-EM Maps

    Published on: July 19, 2024

    2.0K
    Production, Crystallization and Structure Determination of C. difficile PPEP-1 via Microseeding and Zinc-SAD
    13:34

    Production, Crystallization and Structure Determination of C. difficile PPEP-1 via Microseeding and Zinc-SAD

    Published on: December 30, 2016

    11.9K

    结论:

    • 使用3D密度 (proxels) 来生成蛋白质结构,与点云方法相比,具有显著的优势.
    • ProxelGen提供了一个强大的新工具,用于 de novo 蛋白质设计,改进了新性和控制.
    • 基于密度的生成为灵活和可调节的蛋白质结构建模开辟了新的途径.