微塑料探索器 (ToMEx) 的毒性2.0
Leah M Thornton Hampton1, Dana Briggs Wyler1, Bethanie Carney Almroth2
1Toxicology Department, Southern California Coastal Water Research Project Authority, 3535 Harbor Blvd, Suite 110, Costa Mesa, CA USA.
Microplastics and nanoplastics
|September 29, 2025
概括
更新后的微塑料毒性探测器 (ToMEx) 数据库现在包括两倍的微塑料毒性数据,帮助研究人员进行危害表征和对水生动物和人类健康的风险评估.
科学领域:
- 环境毒理学环境毒理学
- 生态毒理学 生态毒理学
- 风险评估 风险评估
背景情况:
- 微塑料毒性探索器 (ToMEx) 数据库,最初于2021年发布,是微塑料毒性数据的关键开源资源.
- 微塑料研究文献的指数式增长使得原来的ToMEx数据库过时,需要更新.
- 该数据库对于微塑料研究界的危害表征和风险评估至关重要.
研究的目的:
- 更新ToMEx数据库,将来自同行评审文献的新毒性数据纳入该数据库,采用众包方法.
- 用更新的数据集和先前建立的框架重新评估基于生态健康的微塑料值.
- 评估更新数据对淡水和海洋环境的值及其不确定性间隔的影响.
主要方法:
- 采用国际众包努力,提取并将新的微塑料毒性数据集成到ToMEx数据库中.
- 一个利用物种灵敏度分布的框架被重新应用,以获得基于生态健康的微塑料值.
- 新提取的数据被选为最低标准,以确定适合值导出.
主要成果:
- ToMEx水生和人类健康数据库的大小大约翻了一番,数据多样性略有增加.
- 大多数先前观察到的趋势,例如较小颗粒大小的毒性增加,持续存在.
- 更新的数据使淡水和海洋区分开来,当包括分子/细胞终点时,海洋值显著下降.
- 值仍然很大,很高的研究比例 (89%) 没有达到值推导的选标准,这表明需要适合目的的数据.
结论:
- 更新的ToMEx数据库 (ToMEx 2.0) 对研究微塑料危害的研究人员显著提高了其价值.
- 淡水和海洋数据的分离揭示了对衍生值的明显影响,特别是对于海洋环境.
- 尽管有所改善,但适用于值推导的研究数量有限,这凸显了环境管理人员的关键数据缺口.
- 未来的ToMEx代可以从人工智能应用中获益,用于数据策划和毒理学结果预测.
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