儿童和青少年在实体器官移植后的内分泌并发症
Ji-Hee Yoon1, Dohyung Kim2, Soojin Hwang2
1Department of Pediatrics, Bundang Jesaeng Hospital, Daejin Medical Center, Seongnam, Gyeonggi-do, Republic of Korea.
Frontiers in endocrinology
|September 29, 2025
概括
固体器官移植 (SOT) 后的儿童经常出现内分泌并发症,影响超过78%的患者. 监测和管理这些问题对于改善SOT后的长期结果和生活质量至关重要.
科学领域:
- 儿科内分泌学 儿科内分泌学
- 移植医学 移植医学
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 固体器官移植 (SOT) 的存活率有所提高,导致儿科接受者内分泌并发症的发病率增加.
- 代谢障碍是SOT后的常见后果,影响生长,发育和整体健康.
研究的目的:
- 调查SOT后儿童和青少年长期内分泌并发症的患病率和类型.
- 在小儿SOT接受者中确定内分泌功能障碍的风险因素和模式.
主要方法:
- 对259名儿科患者 (脏,肝脏,肺,心脏,多器官) 的临床和内分泌学数据的回顾性分析,至少5年随访.
- 收集的数据包括生长参数,肥胖,糖尿病,脱脂症,甲状腺功能,骨健康和青春期发育.
主要成果:
- 超过78%的患者出现了内分泌并发症,在脏/多器官接受者中常见的是矮身,而在肝脏接受者中则是肥胖.
- 接受心脏移植的人群中患糖尿病的发病率很高 (27%),血脂不良的发病率很高 (40.2%).
- 移植前的肥胖和特定的移植因素 (年龄,免疫抑制,排斥) 影响了SOT后的代谢结果.
结论:
- 内分泌和代谢并发症在小儿SOT接受者中非常普遍.
- 有效的监测和管理策略对于优化SOT后的长期健康和生活质量至关重要.
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