高血压患者的LDL-C/HDL-C比率与首次中风之间的关联:一项前性队列研究
Chao Yu1,2, Meihui Wu3,4, Lingjuan Zhu1,2
1Center for Prevention and Treatment of Cardiovascular Diseases, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.
Frontiers in endocrinology
|September 29, 2025
概括
低密度脂蛋白胆固醇 (LDL-C) 与高密度脂蛋白胆固醇 (HDL-C) 的高比例在高血压患者中显著增加了首次中风的风险. 这种联系在当前饮酒者中尤其强烈.
科学领域:
- 心血管医学 心血管医学
- 流行病学 流行病学
- 高血压研究 高血压研究
背景情况:
- 关于LDL-C/HDL-C比率与高血压患者首次中风之间的联系的证据有限.
- 高血压是中风的主要危险因素,因此需要进一步研究对有助于中风的脂质状况.
研究的目的:
- 调查LDL-C/HDL-C比率与第一次中风风险之间的关联.
- 为了评估这种关系,特别是在中国高血压患者的队列中.
主要方法:
- 对12893名中国高血压患者进行前性队列研究.
- 使用了Cox比例危险回归,受限立方线和子组分析.
- 计算了危险比率 (HR) 和95%置信区间 (CI) 来量化风险.
主要成果:
- 每增加1个单位的LDL-C/HDL-C比率,就会增加43%的第一次中风风险 (HR=1.43).
- 在LDL-C/HDL-C比率较高的四分位数中观察到增加中风风险的显著趋势 (趋势P<0.001).
- 这种关联是线性的,并且在当前饮酒者中更强 (P的相互作用=0.024).
结论:
- 升高的LDL-C/HDL-C比率是高血压患者首次中风的重要危险因素.
- 目前饮酒者LDL-C/HDL-C比率高的人面临特别高的风险.
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