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低循环Metrnl水平与老年T2DM患者的腹部脂肪增加有关:基于性别的研究
Jiangli Pei1, Dan Zhao1, Xinhua Ye1
1Department of Endocrinology, the Second People's Hospital of Changzhou, the Third Affiliated Hospital of Nanjing Medical University., Changzhou, Jiangsu Province, People's Republic of China.
较低的血清Metrnl水平与2型糖尿病患者的腹部脂肪增加有关,特别是在男性中. 在这个人群中,Metrnl可能会影响肥胖和代谢健康.
科学领域:
- 内分泌学和新陈代谢学
- 肥胖问题研究研究
- 糖尿病研究 研究 糖尿病研究
背景情况:
- 2型糖尿病 (T2DM) 与身体脂肪分布的改变和代谢功能障碍有关.
- 一种肌蛋白metrnl在新陈代谢调节中具有潜在的作用,但其与T2DM体脂肪的关联尚未得到充分证实.
- 腹部脂肪是T2DM心血管和代谢并发症的关键风险因素.
研究的目的:
- 研究2型糖尿病的中国患者血清Metrnl水平与体脂分布之间的关系.
- 探索Metrnl和肥胖标志物之间潜在的性别特异关联.
- 为了确定Metrnl水平是否与T2DM队列中的腹部肥胖相关.
主要方法:
- 横截面研究包括281名T2DM患者 (195名男性,86名绝经后女性).
- 使用双能X射线吸收计测量身体组成,包括安卓和骨头脂肪.
- 单变量,多变量回归和根据年龄,BMI和脂质进行调整的性别分层分析.
主要成果:
- 血清测量与人体/女性体 (A/G) 脂肪比率和人体脂肪沉积有负相关性.
- 经过多变量调整后,这些关联仍然显著,特别是对于安卓脂肪.
- 与女性相比,在男性中观察到Metrnl和A/G比率/android脂肪之间的更强的负相关性.
结论:
- 较低的血清Metrnl水平与T2DM患者的腹部脂肪增加显著相关.
- 梅特林和腹部脂肪之间的相关性在男性中更为明显.
- Metrnl可能是T2DM中腹部肥胖和代谢功能障碍的潜在生物标志物.
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