根据疫苗接种年龄对HPV疫苗的临床有效性:一个匹配的病例控制研究
Carlos R Oliveira1,2,3, Eugene D Shapiro1,4, Sangini S Sheth5
1Department of Pediatrics, Section of Infectious Diseases and Global Health, Yale School of Medicine, New Haven, CT, USA.
Lancet regional health. Americas
|September 29, 2025
概括
人类乳头瘤病毒 (HPV) 疫苗在18岁之前接种时,对宫病变最有效. 推迟HPV疫苗接种会降低其有效性,这凸显了遵守青少年疫苗接种计划的重要性.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 公共卫生 公共卫生
背景情况:
- 人类乳头瘤病毒 (HPV) 疫苗对于预防宫癌至关重要.
- 在现实世界中,HPV疫苗的有效性需要持续评估.
- 接种疫苗时的年龄是影响HPV疫苗疗效的关键因素.
研究的目的:
- 评估疫苗接种年龄对HPV疫苗有效性的影响.
- 确定HPV疫苗接种年龄与对高度宫病变 (HGCL) 的保护之间的关系.
主要方法:
- 一个匹配的病例控制研究在康涅狄格州纽黑文县进行.
- 这些病例是被诊断为HPV 16/18归因的HGCL的妇女;对照组的巴氏涂片检查正常.
- 用条件逻辑回归分析了疫苗有效性 (VE),并对混因素进行了调整.
主要成果:
- 针对>1个HPV疫苗剂量的整体调整VE为54%.
- 当初剂量在≤18岁时 (75%) 与>18岁 (43%) 相比,VE显著更高.
- 在年龄较大时接种疫苗显示对HPV引起的HGCL的有效性降低.
结论:
- HPV 疫苗的有效性受到首次接种疫苗的年龄的影响.
- 在较年轻的青少年年龄中给予HPV疫苗可以最大限度地保护宫病变.
- 坚持青少年推的HPV疫苗接种计划对公共健康至关重要.
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