在Caprinae肠道微生物群中的胆酸通路:微生物代谢和社区结构的适应性转变
Kai-Meng Shang1,2,3, Rui Liu3, Hong-Bo Ni3
1Integrated Laboratory of Pathogenic Biology, College of Preclinical Medicine, Dali University, Dali, China.
Frontiers in microbiology
|September 29, 2025
概括
羊毛肠道微生物通过独特的途径转化胆汁酸 (BA),其中BA基因载体Bacillota_A主导. 这种独特的微生物新陈代谢会影响宿主健康和营养吸收.
科学领域:
- 微生物生态学 微生物生态学
- 主体与微生物群的相互作用
- 转基因组学是指转基因组学.
背景情况:
- 肠道微生物群对于宿主代谢和免疫非常重要,特别是通过胆酸 (BA) 生物转化.
- 在Caprinae动物 (山羊和绵羊) 中,BA代谢对于营养吸收,免疫调节和肠道平衡至关重要,但具体的微生物和功能尚不清楚.
研究的目的:
- 系统地描述Caprinae肠道微生物群中的微生物多样性,分类学组成和BA相关的代谢途径.
- 为了确定关键的微生物种类和基因参与在Caprinae.内BA生物转化.
主要方法:
- 从Caprinae肠道微生物组中利用了7,530个高质量的元基因组组装基因组 (MAG).
- 采用基因组注释,遗传学推断和统计分析来识别BA转化途径和酶.
- 进行了与人类和猪肠道微生物群的比较分析.
主要成果:
- 确定了一种多样化的Caprinae肠道微生物群,主要由BacillotaA主导,在5,217个MAG中发现了8290个BA相关基因.
- 发现了1,845个编码胆汁盐酸酶 (BSH) 的MAG,这是BA代谢中的关键酶.
- 与人类和猪相比,在Caprinae中发现了独特的BA代谢概况,微生物组成和BA代谢在绵羊肠道的区域特异性差异.
结论:
- 这项研究阐明了Caprinae肠道微生物群的独特的BA代谢能力.
- 强调了携带BSH的MAG的功能潜力及其在宿主微生物群相互作用中的作用.
- 提供了有关健康和疾病的Caprinae肠道微生物组功能的基础见解.
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