利用与营养相关的生物标志物,为中国人口群体开发与营养相关的衰老时钟
Ya-Qing Ma1,2, Ya-Min Dang2, Lv-Tao Zeng1,2
1Fifth School of Clinical Medicine, Peking University, Beijing, China.
Frontiers in nutrition
|September 29, 2025
概括
这项研究揭示了营养生物标志物,身体成分和氧化应激与衰老有关. 一个新的基于营养的衰老时钟准确地预测了生物年龄,有助于个性化干预.
科学领域:
- 老年学是指老年学的学科.
- 生物化学 生物化学
- 生物统计学 生物统计学
背景情况:
- 衰老是一个复杂的过程,受到各种生理和生化因素的影响.
- 了解个体的衰老差异对于开发有效的干预措施至关重要.
- 营养在调节衰老过程和健康结果方面发挥着重要作用.
研究的目的:
- 调查与营养相关的生物标志物,身体成分和人类衰老中的氧化应激之间的关系.
- 开发和验证基于营养的衰老时钟模型,用于预测生物年龄.
- 为个性化干预提供见解,以减轻与年龄相关的衰退.
主要方法:
- 对100名健康参与者 (26-85岁) 血氨基酸和维生素以及尿路氧化应激标志物 (8-oxoGuo, 8-oxodGuo) 的定量分析.
- 使用生物电阻分析 (BIA) 评估身体组成.
- 使用光梯度提升机构建基于营养的衰老时钟模型,通过平均绝对误差 (MAE) 和R平方 (R2) 评估性能.
主要成果:
- 年轻人与老年人之间氧化应激标志物的显著差异.
- 观察到多种氨基酸和维生素的血度的年龄相关变化.
- 老化时钟模型实现了高预测精度 (MAE = 2.5877,R2 = 0.8807),与生理指标相关联.
结论:
- 建立了营养生物标志物,氧化应激,身体组成和生物衰老之间的重要联系.
- 开发的基于营养的衰老时钟是预测生物年龄的可靠工具.
- 为未来关于衰老机制和个性化抗衰老策略的研究提供科学基础.
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