在不孕妇女中MTHFR多态和维生素D状态之间的关联:调解分析
Ruiqiong Zhou1,2, Zhenghong Zhu3, Zhaoyi Wang1
1Center for Reproductive Medicine, Guangdong Women and Children Hospital, Guangzhou, China.
Frontiers in nutrition
|September 29, 2025
概括
在不孕妇女中,MTHFR C677T基因变异增加了维生素D缺乏的风险. 同型氨酸 (Hcy) 部分调解了这种关联,影响了叶酸代谢和生殖健康.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 营养遗传学 营养遗传学
- 临床生物化学 临床生物化学
背景情况:
- 叶酸代谢受损和维生素D缺乏与女性生殖障碍有关.
- 在不孕症中,甲基四叶酸减少酶 (MTHFR) 基因多态,维生素D状况和同类氨酸 (Hcy) 之间的相互作用仍然不清楚.
研究的目的:
- 调查MTHFR基因多态 (C677T和A1298C) 与不育患者的维生素D状态之间的关系.
- 检查Hcy在MTHFR多态和维生素D状态之间的关联中的调解作用.
主要方法:
- 对6344名不育患者的回顾性分析.
- 多变量逻辑和线性回归模型来评估MTHFR多态关系与维生素D状态.
- 顺曲线和斯皮尔曼相关性用于分析Hcy和维生素D水平.
- 调解分析量化直接和间接影响.
主要成果:
- 与CC基因型相比,MTHFR C677T (CT和TT基因型) 与维生素D缺乏和Hcy水平升高的风险显著相关.
- 在MTHFR A1298C多态性方面没有发现显著的关联.
- 血清Hcy与25(OH) D水平和维生素D缺乏率呈现线性相关性.
- 在MTHFR 677CT和TT基因型与维生素D缺乏之间的关联中,Hcy占15.8%和41.6%.
结论:
- MTHFR C677T多态影响维生素D的状态,通过Hcy.介导的直接影响和间接影响.
- 了解这些遗传和代谢相互作用对于管理不孕症和相关的营养不足至关重要.
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