基于受限制立方支线模型的甲状腺功能状态和血清尿酸水平之间的关系:一个横截面研究
Pengxia Qu1, Shuang Yang2, Yaowen Guo1
1Department of Endocrinology, Taiyuan City Central Hospital, Taiyuan, Shanxi Province, People's Republic of China.
Risk management and healthcare policy
|September 29, 2025
概括
甲状腺疾病不会显著影响高尿路血症风险. 然而,在正常范围内增加的自由甲状腺素 (FT4) 水平与高尿素血的风险增加有关.
科学领域:
- 内分泌学 在内分泌学.
- 代谢健康 代谢健康
- 流行病学 流行病学
背景情况:
- 甲状腺功能和尿酸水平之间的关系尚未得到充分证实.
- 高尿路血是各种代谢和心血管疾病的危险因素.
研究的目的:
- 为了研究甲状腺疾病,甲状腺激素水平和高尿血的相关性.
- 分析不同甲状腺功能状态对尿酸水平的影响.
主要方法:
- 从太原地区的健康查数据的回顾性分析.
- 按甲状腺疾病类型,甲状腺功能指数 (FT4,FT3,TSH) 和血清尿酸水平 (SUA) 分类参与者.
- 统计分析包括后勤回归和限制立方线 (RCS) 建模.
主要成果:
- 患病率:临床甲状腺功能障碍症 (0.9%),亚临床甲状腺功能障碍症 (0.7%),临床甲状腺功能障碍症 (0.8%),亚临床甲状腺功能障碍症 (13.7%) 和高尿路血 (16.9%).
- 超尿路血的患病率随着FT4和FT3的升高而增加,随着TSH的降低而下降.
- 在同变性调整后,甲状腺疾病状态与高尿素血症没有显著相关;只有FT4显示出显著的影响 (OR 1.028).
- 在FT4水平和正常范围内的高尿路血症风险之间观察到一种积极的剂量反应关系,FT4> 16.85 pmol/L被确定为危险因素.
结论:
- 甲状腺疾病状态没有显著影响hyperuricemia.
- 在正常范围内升高的自由甲状腺素 (FT4) 水平与高尿素血的风险增加有关.
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