相关实验视频

Updated: Jan 16, 2026

Sex Stratified Neuronal Cultures to Study Ischemic Cell Death Pathways

Sex Stratified Neuronal Cultures to Study Ischemic Cell Death Pathways

Published on: December 9, 2013

在人类皮质解剖学中性别差异的分化

Hyo M Lee¹, Siyuan Liu¹, Elisa Guma^1,2

¹Section on Developmental Neurogenomics, National Institute of Mental Health, Bethesda, Maryland, United States.

bioRxiv : the preprint server for biology

|September 29, 2025

概括

人类大脑结构显示皮质体积,表面积和厚度的性别差异. 这些变异与X染色体剂量和性腺激素有关,为大脑发育提供了洞察力.

科学领域:

神经科学是一个神经科学.
人类的神经成像
发育神经科学的发展神经科学.

背景情况:

在人类区域皮质体积 (CV) 中存在可复制的性别差异.
表面积 (SA) 和皮层厚度 (CT) 对这些CV性别差异的具体贡献尚未得到充分理解.
对人类因果驱动因素的直接实验研究是有限的.

研究的目的:

量化和空间解决SA和CT对人类CV性别差异的差异贡献.
为了研究X染色体剂量和性腺激素在性别偏差皮质组织中的作用.

主要方法:

分析了来自两个独立的人类队伍 (N=1,754) 的结构神经成像数据,以区分SA和CT对CV性别差异的贡献.
来自性染色体形变异和GnRH缺乏症 (N=313) 的临床队列的神经成像数据被用于评估遗传和荷尔蒙影响.

主要成果:

CV,SA和CT中的性别差异是可复制和空间解决的,与不同的功能网络保持一致.
带有性别偏差的皮质组织的区域显示与X染色体剂量 (例如,感官皮质,岛屿皮质) 和淋巴腺激素 (例如,前部,部-尾-尾区域) 相关的一致效应.

结论:

这项研究消除了性别对人类皮质区域CV,SA和CT的影响.
研究结果提名了潜在的遗传 (X染色体) 和内分泌 (淋巴腺激素) 原因,用于观察到性别偏差的皮质组织.

更多相关视频

How to Measure Cortical Folding from MR Images: a Step-by-Step Tutorial to Compute Local Gyrification Index

How to Measure Cortical Folding from MR Images: a Step-by-Step Tutorial to Compute Local Gyrification Index

Published on: January 2, 2012

Symmetric Bihemispheric Postmortem Brain Cutting to Study Healthy and Pathological Brain Conditions in Humans

Symmetric Bihemispheric Postmortem Brain Cutting to Study Healthy and Pathological Brain Conditions in Humans

Published on: December 18, 2016

相关概念视频

Cerebral Hemispheres

Cerebral Hemispheres

The human brain, a complex organ, is functionally divided into two cerebral hemispheres—left and right. These hemispheres are interconnected by a structure of paramount importance, the corpus callosum. This substantial bundle of neural fibers is not just a bridge between the hemispheres but a crucial element for the brain's comprehensive functioning. It enables efficient communication between the two hemispheres, allowing each side of the brain to control and receive sensory and motor...

The Ratio of X Chromosome to Autosomes

The Ratio of X Chromosome to Autosomes

In most organisms, sex is determined by the ratio of X and Y chromosomes. However, in some organisms, such as Drosophila and C.elegans, sex is determined by the ratio of the number of X chromosomes to the number of sets of autosomes. The Y chromosome in Drosophila is active but does not determine sex. It contains genes responsible for the production of sperms in adult flies.
Normal male Drosophila has a ratio of one X chromosome to two sets of autosomes. In contrast, normal female...

Lateralization

Lateralization

Brain lateralization refers to the division of mental processes and functions between the two hemispheres of the brain, a phenomenon that optimizes neural efficiency and underpins complex abilities in humans. This specialization allows each hemisphere to perform tasks where it has a comparative advantage, facilitating more refined cognitive capabilities across different domains.