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在加工的Fuzi中解读结构-组成-有效性转换:一个集成的SEM,XRD,代谢学和药理学方法

Yang Yang¹, Xuemei Wei¹, Shuya Zhang²

¹Shenzhen Baoan Authentic TCM Therapy Hospital, Shenzhen, China.

Frontiers in chemistry

|September 29, 2025

概括

处理Aconiti Lateralis Radix Praeparata (Fuzi) 显著影响其安全性和有效性. 了解这些结构和化学变化是标准化这种重要的草药以获得更好的治疗结果的关键.

科学领域:

药理学药理学是指药理学的学科.
草药是一种草药.
分析化学分析化学

背景情况:

阿科尼蒂 (Aconiti Lateralis Radix Praeparata) 是一种重要的但有毒的草药.
多样化的加工方法在标准化方面带来了挑战,影响了解毒和治疗效果.

研究的目的:

调查在Fuzi加工过程中的结构,组成和功能变化.
确定加工,化学成分和治疗效果之间的相关性.

主要方法:

使用SEM,XRD,代谢学和药学动力学评估进行综合性分析.
对9种加工变种的分析.

主要成果:

加工技术改变了粉颗粒形态.
代谢学发现了57种双类类化合物,其含量在各个变体之间有所不同.
药理动力学分析显示,与加工相关的疗效安全性权衡.

结论:

处理方法极大地影响了富士的结构,成分和治疗特征.
洞察力为完善富士加工提供了基础,以实现最佳的安全性和有效性.
这项研究推动了传统草药的标准化工作.

关键词:

富士人富士人富士人标准化TCM处理的标准化有效性-安全性平衡的平衡.代谢生物组的代谢生物组粉超结构是一种超结构.

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