在患有自闭症的儿科患者中,由于严重的维生素B12缺乏导致的伪血栓性微血管病变:一个病例报告
Ilana Walters1,2, Caroline Malcolmson1,3, Renee Potashner1,3
1Department of Paediatrics, University of Toronto, Toronto, ON, Canada.
SAGE open medical case reports
|September 29, 2025
概括
严重的维生素B12缺乏会导致中性贫血和溶血性贫血,特别是在患有自闭症谱系障碍和食物限制的儿童中. 及时补充B12可以迅速解决这些血液学异常.
科学领域:
- 血液学 血液学 血液学
- 儿科 儿科 儿科
- 营养科学 营养科学
背景情况:
- 维生素B12缺乏通常会导致巨细胞性贫血.
- 很少,它呈现为伪微血管病变性血液溶解性贫血或多系细胞衰竭.
- 自闭症谱系障碍与选择性饮食有关,增加营养缺乏症的风险.
研究的目的:
- 报告一名患有自闭症谱系障碍的儿科患者严重缺乏维生素B12的罕见病例.
- 为了突出维生素B12缺乏的血液学表现.
- 强调微量营养素查在脆弱儿科群体中的重要性.
主要方法:
- 一个12岁的男性患有自闭症谱系障碍,呈现出宪法症状的案例报告.
- 实验室评估显示严重的中性质衰竭,溶血性贫血和无法检测的维生素B12水平.
- 治疗包括肌肉内和口服维生素B12补充剂.
主要成果:
- 患者表现出严重的中性衰竭和血液溶解性贫血.
- 维生素B12水平极低,与严重的食物限制有关.
- 血液学参数和中性粒细胞数量在维生素B12治疗13天内正常化.
结论:
- 维生素B12缺乏可以表现为严重的血液异常,包括中性质衰竭和血液溶解性贫血.
- 自闭症谱系障碍和相关的食物限制是维生素B12缺乏的危险因素.
- 检查微量营养素缺乏症对于限制饮食的儿科患者来说至关重要,以防止严重的并发症.
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