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评估肺栓塞的长期关键结果和安全性:EKOS-PE研究
Sameh Sayfo1, Taylor Pickering2, Ghadi Moubarak2
1Department of Cardiology, Baylor Scott & White The Heart Hospital - Plano, Plano, Texas.
Journal of the Society for Cardiovascular Angiography & Interventions
|September 29, 2025
概括
在大规模或亚大规模肺栓塞 (PE) 患者中,Ekosonic内血管系统 (EKOS) 显示出较低的死亡率和改善的右心室功能. 长期的结果显示了良好的生活质量,支持其用于高风险PE.
科学领域:
- 心脏病学 心脏病学
- 肺部医学 肺部医学
- 医疗器械 医疗器械
背景情况:
- 肺栓塞 (PE) 具有显著的发病率和死亡率风险,特别是在大规模和次大规模病例中.
- 右心室 (RV) 应变和长期并发症在严重的PE中很常见.
- 爱科索尼内血管系统 (EKOS) 是一种导管导向的血栓溶解选择,适用于不适合系统性血栓溶解的PE患者,但长期数据有限.
研究的目的:
- 评估与EKOS治疗大规模或亚大规模PE相关的长期死亡率.
- 评估EKOS治疗对RV功能和RV/LV比率的影响.
- 确定使用EKOS治疗PE的患者的长期生活质量 (QoL).
主要方法:
- 对137名大规模或亚大规模PE患者进行了回顾性队列研究,这些患者接受了EKOS治疗 (2020-2024).
- 主要结局:全因死亡率.
- 二次结局:RV/LV比率的变化,残留的RV功能障碍,通过肺栓塞生命质量调查问卷的QoL.
主要成果:
- 全因死亡率为7.2%,平均随访时间为26.5个月.
- 平均RV/LV比率显著下降 (1.13至0.83,P<.01).
- 75.5%的患者没有残留的RV功能障碍;11.5%的患者有中度至重度的功能障碍. 质量质量调查显示症状最小,肺部健康状况改善.
结论:
- 对于PE患者来说,EKOS治疗与VR功能显著的长期改善有关.
- 这种治疗与低死亡率和良好的感知生活质量有关.
- EKOS疗法支持当前管理高危PE的指导方针建议.
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