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代谢酶活性变化的影响对达布拉费尼布的处置

Shi-Yu Wang1,2, Qing Chen3, Zhong-Xi Chen2

  • 1Wenzhou Medical University Wenzhou Seventh People's Hospital, Wenzhou, Zhejiang, China.

Frontiers in pharmacology
|September 29, 2025
PubMed
概括

洛拉塔丁通过抑制其代谢,显著增加了达布拉费尼布的暴露,而CYP3A4的遗传变异也影响了达布拉费尼布的药理动力学. 当这些因素并存时,剂量调整至关重要.

关键词:
在 CYP3A4 中.达布拉芬尼布的使用情况药物相互作用 药物相互作用遗传多形态主义是一种遗传多形态主义.洛拉塔丁类药物 洛拉塔丁类药物

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