空塞拉综合征:对 pituitary 功能的长期影响
Latifa Yagoubi1, Amal Ourdi1, Nisrine Bouichrat1,2
1Department of Endocrinology-Diabetology and Nutrition, Mohammed VI University Hospital Center, Faculty of Medicine and Pharmacy, University of Mohammed 1st, Oujda, Morocco.
Journal of medicine and life
|September 29, 2025
概括
空塞拉综合征 (ESS) 经常导致垂体激素缺乏,特别是影响上腺和淋巴腺轴. 诸如年龄和较高的BMI等因素加剧了这些缺陷,需要定期进行内分泌监测.
科学领域:
- 内分泌学 在内分泌学.
- 神经成像是一种神经成像.
- 内部医学 内部医学
背景情况:
- 空塞拉综合征 (ESS) 涉及到脑脊液进入垂体的,可能导致垂体功能障碍.
- 虽然ESS往往无症状,但可以导致逐渐的荷尔蒙缺乏,但长期研究很少.
研究的目的:
- 为了评估ESS患者的垂体功能.
- 为了监测随着时间的推移激素缺乏症的进展.
- 探索性别,年龄和BMI对ESS下垂体功能的影响.
主要方法:
- 在2014年至2024年期间治疗41名ESS患者的描述性和分析性研究.
- 使用MRI和综合性内分泌检测 (皮质醇,TSH,FT4,益生素,GH,性腺激素,丸激素).
- 随访时间中位数为5年 (范围:6个月至10年),数据使用SPSS v.21.21进行分析.
主要成果:
- 82.9%的患者在诊断时至少有一种垂体激素缺乏,主要影响上腺,淋巴腺和生长激素轴.
- 与男性 (21.9%) 相比,女性发生性腺功能障碍的发生率更高 (34.1%).
- 年龄与上腺/上腺功能不充分正相关,较高的BMI与上腺功能不充分显著相关.
结论:
- ESS经常与垂体功能障碍有关,特别是在上腺和淋巴腺轴.
- 性别,年龄和BMI是影响ESS患者激素缺乏症发展和进展的重要因素.
- 定期内分泌评估和长期随访对于管理ESS患者至关重要.
关键词:
体重指数 (BMI),人体质量指数.脑脊髓,脑脊液,脑脊液等图像扫描,计算机断层扫描.ESS,空的塞拉综合征空的塞拉图尔基卡 (Sella Turcica) 是一个空的塞拉图尔基卡.FSH,卵泡刺激激素 (FSH) 是一种激素.FT4,免费的甲状腺素.GH,生长激素,生长激素的人生激素.GHD,生长激素缺乏症,生长激素缺乏症IGF-1,类似胰岛素的生长因子1ITT,胰岛素耐受性测试LH,黄素化激素 (Luteinizing Hormone) 是一种激素.磁共振成像,磁共振成像,磁共振成像PRL, 孕产腺素, 孕产腺素在ST,Synacthen测试试验.转激素,甲状腺激素,甲状腺激素性别差异是性别之间的差异.这是一种低性性性性性性.下垂体功能不充分的情况.相关概念视频
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