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The Effect of Aging on Tissues01:19

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Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
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Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
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Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
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大脑功能和结构的关节衰老模式使用27,793个样本揭示

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科学领域:

  • 神经科学是一个神经科学.
  • 衰老研究研究 衰老研究
  • 脑部成像 脑部成像

背景情况:

  • 老化显著改变大脑的结构和功能.
  • 功能网络连接 (FNC) 和灰色物质体积 (GMV) 在老化过程中的变化之间的相互作用尚未完全理解.

研究的目的:

  • 开发一个统一的框架,用多式模式的大脑数据来预测年龄.
  • 识别和验证FNC和GMV与衰老相关的变化.
  • 研究关节功能结构衰老模式及其与认知衰退的关联.

主要方法:

  • 利用了一大批英国生物库数据集 (27,793名健康受试者,年龄49-76岁).
  • 采用单模和多模方法进行年龄预测.
  • 开发了一种新的分析,以揭示FNC和GMV的关节衰老模式.

主要成果:

  • 多模式年龄预测的表现优于单一模式.
  • 在小脑,额头极,状圈和前皮层中发现FNC和GMV的协同下降.
  • 在部区域观察到矛盾的变化 (增加FNC,减少GMV),表明补偿.
  • 在特定区域的FNC和GMV的联合下降与反应时间相关.

结论:

  • 多模式大脑分析对于理解衰老至关重要.
  • 衰老涉及到不同的关节功能结构变化,具有特定区域的模式.
  • 这些变化与认知功能有关,为与年龄相关的认知恶化提供了见解.