免疫学,免疫疗法和瘤微环境在肝细胞癌:一个全面的审查
Miho Akabane1, Yuki Imaoka2, Ghee Rye Lee1
1Department of Surgery, The Ohio State University Wexner Medical Center and James Comprehensive Cancer Center, Columbus, OH, USA.
Expert review of clinical immunology
|September 29, 2025
概括
肝细胞癌 (HCC) 免疫疗法显示出希望,但面临挑战. 进步需要重新编程瘤微环境 (TME) 并使用多参数生物标志物进行个性化策略,以改善患者的治疗结果.
科学领域:
- 肝细胞癌 (HCC) 研究研究
- 癌症免疫学 癌症免疫学
- 免疫治疗是一种免疫疗法.
背景情况:
- 在全球范围内,HCC是癌症死亡的主要原因.
- 在HCC中,瘤微环境 (TME) 是免疫抑制的,阻碍了免疫监测.
- 目前的免疫疗法提供了变革性的潜力,但有限的持久反应.
研究的目的:
- 综合最近在HCC免疫学方面的进展.
- 审查针对HCC的免疫疗法策略.
- 探索TME在HCC中的作用.
主要方法:
- 在PubMed和ClinicalTrials.gov的文献搜索 (2001年1月至2025年5月).
- 专注于临床和翻译研究.
- 对免疫学景观,TME成分,免疫疗法相互作用,耐药性机制和生物标志物的审查.
主要成果:
- 免疫细胞 (T细胞,NK细胞,巨细胞等) 的详细轮. 和TME因子 (纤维细胞,细胞因子,血管生成等). 在HCC中.
- 免疫疗法相互作用,耐药性机制和组合策略的描述.
- 对患者分层的新兴生物标志物 (三级淋巴体结构,PD-L1,TMB,基因特征,肠道微生物群) 的审查.
结论:
- 免疫疗法已经推进了HCC管理,但面临着诸如耐药性和生物标志物限制等挑战.
- 未来的进步需要TME重编程,多参数生物标志物和个性化策略.
- 与其他方法的整合可能会导致精确的免疫瘤学,并改变HCC管理.
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