淋巴系统和免疫器官的微生理系统
Ishita Jain1,2,3, Ankur Singh1,2,3, Andrés J García1,2
1Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA, USA.
Advanced healthcare materials
|September 29, 2025
概括
微生理系统 (MPS) 中的工程淋巴系统对于模拟疾病和药物开发至关重要. 将淋巴细胞整合到MPS中可以提高对免疫监测和组织平衡的理解,以便更好地进行治疗测试.
科学领域:
- 生物医学工程 生物医学工程
- 免疫学 免疫学 免疫学
- 血管生物学 血管生物学
背景情况:
- 具有血液血管的微生理系统 (MPS) 对疾病建模和药物开发至关重要.
- 淋巴系统对液体平衡和免疫反应至关重要,在当前的体外模型中基本上缺席.
- 淋巴功能障碍与淋巴,炎症和癌症转移有关.
研究的目的:
- 在基于生物材料的MPS中审查工程淋巴微环境和免疫器官的进步.
- 突出重现用于重建本地淋巴组织的生物化学和生物物理复杂性的策略.
- 强调淋巴结合MPS在疾病研究和治疗开发方面的潜力.
主要方法:
- 调查基于生物材料的MPS工程的近期进展.
- 突出淋巴结合的创新策略,包括可调节的ECM,人性化的细胞和精密制造.
- 讨论可灌输,模块化和可扩展的模型开发.
主要成果:
- 工程淋巴微环境和免疫有机体正在MPS中取得进展.
- 可调节的生物材料,先进的细胞采购和精密制造使得淋巴复杂性的重建成为可能.
- 与多器官系统和计算建模的集成提供了个性化的免疫模型.
结论:
- 将淋巴细胞纳入下一代MPS对于研究免疫监测和组织稳态至关重要.
- 淋巴结合的MPS将揭示疾病机制,并加速预测性治疗平台的开发.
- 这种方法有望改善药物开发和再生医学的临床翻译.
相关概念视频
Functions of the Lymphatic and Immune System
6.5K
The lymphatic system plays a crucial role in bolstering our immune system. It consists of a network of lymphoid organs, lymph, and lymphatic vessels that provide structural and functional support in safeguarding the body against pathogens such as viruses and bacteria.
The primary lymphoid organs, including the bone marrow and the thymus, serve as the maturation sites for lymphocytes. Secondary lymphoid organs, like the mucosa-associated lymphoid tissue, activate these lymphocytes and serve as...
The primary lymphoid organs, including the bone marrow and the thymus, serve as the maturation sites for lymphocytes. Secondary lymphoid organs, like the mucosa-associated lymphoid tissue, activate these lymphocytes and serve as...
6.5K
Introduction to Lymphatic and Immune System
16.6K
Immunity is a crucial biological concept about our body's inherent capacity to prevent infections and diseases. A complex network of cells and tissues collectively known as the immune system facilitates this natural defense mechanism. The immune system plays an integral role in maintaining our health and well-being, shielding us from potential health threats.
The immune responses can be categorized into two types: innate and adaptive. Innate immunity comprises nonspecific defenses we are...
The immune responses can be categorized into two types: innate and adaptive. Innate immunity comprises nonspecific defenses we are...
16.6K
Secondary Lymphoid Organs
8.9K
Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
8.9K
Lymphoid Cells and Tissues
2.9K
Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
2.9K
Lymphatic Vessels and Lymph Transport
22.0K
Lymphatic vessels, known as lymphatics, are crucial in transporting lymph from peripheral tissues to our venous system. This process begins with lymph entering through tiny capillaries that branch through tissues. These capillaries have unique features such as larger diameters, thinner walls, and a distinctive one-way valve system formed by overlapping endothelial cells.
This one-way system allows fluids, solutes, and even pathogens to enter but prevents their return to the intercellular...
This one-way system allows fluids, solutes, and even pathogens to enter but prevents their return to the intercellular...
22.0K
Development of the Lymphatic System
2.0K
The development of lymphatic tissues and vessels in embryonic life begins around the fifth week. These structures originate from the mesoderm layer, with lymph sacs emerging from developing veins.
The first lymph sacs to form are the paired jugular lymph sacs located at the junction of the internal jugular and subclavian veins. From these sacs, lymphatic capillary plexuses extend to the thorax, upper limbs, neck, and head, eventually forming lymphatic vessels. Each jugular lymph sac maintains a...
The first lymph sacs to form are the paired jugular lymph sacs located at the junction of the internal jugular and subclavian veins. From these sacs, lymphatic capillary plexuses extend to the thorax, upper limbs, neck, and head, eventually forming lymphatic vessels. Each jugular lymph sac maintains a...
2.0K


