威斯康星州纵向研究中的痴呆症患病率
Victoria J Williams1,2,3,4, Ralph Trane1, Kamil Sicinski4
1Department of Medicine, Division of Geriatrics and Gerontology, University of Wisconsin-Madison, School of Medicine and Public Health, Madison, Wisconsin, USA.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|September 29, 2025
概括
在威斯康星州纵向研究 (WLS) 中,痴呆的患病率在81岁时为8.9%. 这项研究利用了广泛的生命周期数据来探索痴呆症的社会生物学决定因素.
科学领域:
- 老年学是指老年学的学科.
- 流行病学 流行病学
- 神经科学是一个神经科学.
背景情况:
- 很少有寿命队列具有良好的特征痴呆症结果,以研究社会生物学决定因素.
- 威斯康星州纵向研究 (WLS) 是美国的一项全面的寿命队列研究.
- 了解痴呆症的患病率及其决定因素对于公共卫生至关重要.
研究的目的:
- 为了确定威斯康星州纵向研究 (WLS) 队列中的痴呆症患病率.
- 利用WLS广泛的生命周期数据来调查影响痴呆症的社会生物学因素.
- 在WLS中为持续的痴呆症发病率和生物标志物研究奠定基础.
主要方法:
- 针对性多阶段评估方法用于痴呆症分类.
- 参与者接受了基于电话的认知查,随后对那些低于切断线的人进行了深入评估.
- 基于共识的认知诊断和疑似病因 (包括阿尔茨海默病) 被确定.
主要成果:
- 在WLS队列中,痴呆的患病率为8.9%,平均年龄为81岁.
- 在确诊的痴呆病例中,79%被认为是由于阿尔茨海默病 (AD).
- 对5414名参与者的认知状态进行了确定.
结论:
- WLS为痴呆症研究提供了一个有价值的资源,即前性收集的生命周期数据.
- 将WLS数据与痴呆症结果结合起来,可以探索痴呆症的整个生命过程决定因素.
- 未来的研究将涉及代评估,医疗保险索赔链接和AD生物标志物分析.
更多相关视频
09:38Generalized Psychophysiological Interaction PPI Analysis of Memory Related Connectivity in Individuals at Genetic Risk for Alzheimer's Disease
Published on: November 14, 2017
15.6K
12:28Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains
Published on: June 3, 2020
18.1K
相关概念视频
01:30Dementia
523
Dementia is a collective term for cognitive disorders primarily affecting memory, thinking, and reasoning. It is not a specific disease but a syndrome, with Alzheimer's disease being the most common cause, accounting for approximately 60-80% of cases. Other types include vascular dementia, Lewy body dementia, and frontotemporal dementia. Dementia affects millions worldwide, particularly older adults, though it is not a normal part of aging.
The progression of dementia is generally gradual....
The progression of dementia is generally gradual....
523
01:26Alzheimer's Disease: Overview
1.6K
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
1.6K
02:20Longitudinal Research
13.1K
Sometimes we want to see how people change over time, as in studies of human development and lifespan. When we test the same group of individuals repeatedly over an extended period of time, we are conducting longitudinal research. Longitudinal research is a research design in which data-gathering is administered repeatedly over an extended period of time. For example, we may survey a group of individuals about their dietary habits at age 20, retest them a decade later at age 30, and then again...
13.1K
01:26Longitudinal Studies
479
Longitudinal studies are also widely used in other medical and social science fields. For instance, in cardiovascular research, they can monitor patients' health over decades to identify risk factors for heart disease, such as high cholesterol or smoking, and evaluate the long-term effectiveness of preventive measures. Similarly, in mental health studies, researchers might follow individuals from adolescence into adulthood to understand the development and progression of conditions like...
479
01:22Alzheimer's Disease: Treatment
824
Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...
824
01:30Cognitive Development During Adulthood
780
Cognitive development continues throughout adulthood, undergoing significant shifts across early, middle, and late stages. Individual transition occurs from adolescent idealism to pragmatic and adaptable thinking in early adulthood. During this period, individuals learn to integrate personal beliefs with the recognition that other perspectives are equally valid. Exposure to the complexities of modern society, diverse experiences, and higher education contribute to this adaptive thought process,...
780