试管婴儿成功故事对治疗决策的影响:在线随机对照试验
Verity Chadwick1, Micah B Goldwater2, Tom van Laer3
1Women's and Babies, Royal Prince Alfred Hospital, Camperdown, NSW, Australia.
概括
试管婴儿受精 (IVF) 的成功案例可能会导致患者继续治疗,尽管成功率低. 医疗保健提供者应讨论现实的结果,以管理患者的期望.
科学领域:
- 生殖医学 生殖医学
- 决策的心理学 决策的心理学
背景情况:
- 试管婴儿 (IVF) 提供了生育解决方案,但也带来了负担,包括不切实际的患者期望和长期治疗.
- 人们对患者无限期地继续进行试管婴儿存在担忧,即使成功的可能性很小.
研究的目的:
- 调查试管婴儿成功事是否会影响假设的意图继续治疗,尽管成功概率非常低.
- 评估成功和失败事对治疗延续意向的影响.
主要方法:
- 在澳大利亚进行了一项在线随机对照试验,其中有606名女性参与者 (年龄在18-45岁).
- 参与者观看了6次不成功的试管婴儿周期的图片,成功率为<5%,并随机分配到: 1) 成功事, 2) 成功和失败事,或 3) 没有事.
- 测量结果包括另一个试管婴儿周期的意图,担忧,感知成功概率和叙事运输.
主要成果:
- 与对照组相比,收到事 (积极或混合) 的参与者表现出更高的意图接受另一个试管婴儿周期 (P=0.017).
- 在担忧,感知成功可能性或跨组叙事传输方面没有发现显著差异.
- 在考虑先前的试管婴儿经验的调整分析中,事对意图的影响并不显著.
结论:
- 事,特别是成功案例,可能会鼓励继续试管婴儿治疗,即使成功几率极低.
- 以前有过试管婴儿经验的患者往往高估了成功的可能性,强调了需要坦率地讨论治疗结果的必要性.
- 医疗保健提供者应该注意成功故事如何影响患者对IVF延续的决策.
相关概念视频
01:13Randomized Experiments
8.9K
The randomization process involves assigning study participants randomly to experimental or control groups based on their probability of being equally assigned. Randomization is meant to eliminate selection bias and balance known and unknown confounding factors so that the control group is similar to the treatment group as much as possible. A computer program and a random number generator can be used to assign participants to groups in a way that minimizes bias.
Simple randomization
Simple...
Simple randomization
Simple...
8.9K
01:52Regression Toward the Mean
6.8K
Regression toward the mean (“RTM”) is a phenomenon in which extremely high or low values—for example, and individual’s blood pressure at a particular moment—appear closer to a group’s average upon remeasuring. Although this statistical peculiarity is the result of random error and chance, it has been problematic across various medical, scientific, financial and psychological applications. In particular, RTM, if not taken into account, can interfere when...
6.8K
01:11Clinical Trials: Overview
4.6K
Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
4.6K
01:23Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches
407
Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
407
01:16Clinical Trials
10.1K
Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
There are four phases in a clinical trial. A phase one...
10.1K
01:11Blinding
3.8K
Blinding is a commonly used method of not telling participants which treatment a subject is receiving. Blinding is a critical part of a randomized control trial or RCT. It reduces the bias that affects the results. In an RCT, blinding is used in the form of a placebo. A placebo effect occurs when untreated subjects falsely believe they have received the treatment and report improved symptoms. A placebo or a dummy treatment is administered to subjects to negate the bias caused by such an effect.
3.8K