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Updated: Jan 16, 2026

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改性解锁核酸 (MUNA) 减轻了小干扰RNA的目标外影响

Shohei Mori1, Dhrubajyoti Datta1, Lydia Perkins1

  • 1Alnylam Pharmaceuticals, 675 West Kendall, Cambridge, MA 02142, United States.

Nucleic acids research
|September 29, 2025
PubMed
概括

改性解锁核酸 (UNA) 类似物被合成并纳入短干扰RNA (siRNA). 这些修改后的siRNAs显示了RNA干扰疗法的潜力,减少了目标外效应.

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