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Updated: Jul 29, 2026

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通过调节TFAM,PGC1A恢复线粒体健康,通过调节TFAM在镜片上皮纤维化期间减轻EMT

Jingqi Huang1, Peiyi Jiang1, Baoxin Chen1

  • 1State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou, People's Republic of China.

Investigative ophthalmology & visual science
|September 29, 2025
PubMed
概括

过氧体增殖器激活受体 γ 协同激活器 1-α (PGC1A) 通过改善透镜上皮细胞 (LEC) 中的线粒体功能来保护纤维性白内障. 抑制PGC1A可能为透镜上皮纤维化提供治疗策略.

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相关概念视频

TGF - β Signaling Pathway01:16

TGF - β Signaling Pathway

The TGF-β signaling pathway regulates cell growth, differentiation, adhesion, motility, and development. TGF-β ligands that induce TGF-β signaling are synthesized in their latent form. Several proteases or cell surface receptors such as integrins act upon the latent form, releasing the active ligand. There are three types of mammalian TGF-βs: (TGF-β1, TGF-β2, and TGF-β3) that bind as homodimers or heterodimers to TGF-β receptors. The TGF-β receptors are of three kinds RI, RII, and RIII. The RI...