功能性肠道疾病的全球流行,特征和影响
N Tornkvist1, O S Palsson2, J Hreinsson1
1Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
The American journal of gastroenterology
|September 29, 2025
概括
功能性肠道疾病 (FBD) 在世界各地很常见,影响生活质量和医疗保健使用. 诊断标准的变化会影响患病率,但FBD对健康的负面影响在全球范围内仍然存在.
科学领域:
- 胃肠病学 胃肠病学
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 功能性肠道疾病 (FBD) 在全球普遍存在,严重影响患者的生活.
- 关于FBD的全球流行和影响的数据有限.
研究的目的:
- 通过罗马基金会全球流行病学研究 (RFGES) 的互联网数据来确定FBD的全球流行率.
- 分析FBD与心理症状,身体症状,生活质量 (QoL) 和医疗保健利用的关联.
- 调查刺激性肠综合征 (IBS) 标准变化 (罗马III至IV) 对患病率的影响.
主要方法:
- 通过RFGES利用来自26个国家的互联网数据.
- 评估了FBD患病率,心理和体质症状,生活质量,人口统计,病史和医疗保健使用情况.
- 基于罗马三号和罗马四号标准的IBS患病率在14个国家进行比较.
主要成果:
- 33.2%的人符合任何FBD的罗马IV标准;功能性便秘 (11.7%) 和未指定的FBD (8.7%) 是最常见的.
- FBD患者表现出更多的非GI体质/心理症状,降低了QoL,以及更高的医疗利用率,特别是IBS和阿片类药物诱导的便秘 (OIC).
- 由于症状频率值,罗马IV标准显著降低了IBS患病率 (4.1%),相比罗马III (10.1%),尽管健康影响仍然存在.
结论:
- 在全球范围内,FBD是常见的,在各个地区都有一致的健康影响.
- 诊断标准的变化会影响IBS的患病率,但不会影响FBD对健康的整体负面影响.
- FBD严重影响日常生活,需要持续的研究和管理策略.
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