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Updated: Jan 16, 2026

Using Next Generation Sequencing to Identify Mutations Associated with Repair of a CAS9-induced Double Strand Break Near the CD4 Promoter
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对核酸相似物的检查点依赖性敏感性揭示了基因组不稳定的特定模式

Zainab Burhanuddin Kagalwala1,2, Mohammed Ayan Chhipa1,3, Zohreh Kianfard1,3

  • 1Department of Chemistry and Biology, Faculty of Science, Toronto Metropolitan University, Toronto, ON M5B 2K3, Canada.

Current issues in molecular biology
|September 29, 2025
PubMed
概括

基因复制检查点突变会对核酸相似物产生独特的敏感性. 了解这些概况可以预测耐药性,并个性化癌症治疗策略.

关键词:
在DNA损伤和修复过程中.DNA复制的不稳定性艾滋病病毒抗逆转录病毒.细胞周期检查点检查点裂变酵母屏 裂变酵母屏基因组的不稳定性一半最大的抑制度 (IC50)核酸类似物 核酸类似物合成杀伤性 合成杀伤性

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