针对雄激素受体信号通路的天然产品:治疗潜力和机制
Sitong Wu1, Esveidy Isabel Oceguera Nava1, Dennis Ashong1
1Department of Chemistry & Biochemistry, California State University, Fresno, CA 93740, USA.
Current issues in molecular biology
|September 29, 2025
概括
自然产品提供了针对雄激素受体 (AR) 信号通路的新策略,这是前列腺癌中至关重要的. 对这些化合物的进一步研究可能会导致对抗割的前列腺癌 (CRPC) 的新疗法.
科学领域:
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
- 自然产品 化学 化学
背景情况:
- 雄激素受体 (AR) 信号驱动前列腺癌,包括抵抗割的前列腺癌 (CRPC).
- 目前的AR向疗法面临着不可避免的耐药性,需要新的治疗策略.
- 自然产品是生物活性化合物的多样化来源,具有调节AR信号的潜力.
研究的目的:
- 审查自然产品与AR信号轴相互作用的机制.
- 突出自然产品在克服前列腺癌药物耐药性的潜力.
- 确定基于天然产品的AR调制的挑战和未来研究方向.
主要方法:
- 对针对AR信号通路的天然产品研究的文献综述.
- 自然产品机制的分类,包括直接的AR对抗,降解和间接调制.
- 对临床前证据的分析和研究缺口的识别.
主要成果:
- 自然产品通过多种机制向AR:抑制的产生,5α-减少酶,AR对抗性,降解,核转位干扰和AR拼接变体的调制.
- 化合物还通过表观遗传调节,微RNA调节和协调器干扰间接抑制AR信号.
- 临床前数据显示,这些药物可以通过中断AR信号来抑制前列腺癌的生长.
结论:
- 天然产品在调节前列腺癌中AR信号方面显著有前途.
- 挑战包括有限的药理动力学数据,缺乏体内验证和少数临床研究.
- 未来的研究应该集中在生物可用性,组合疗法和强大的体内/临床研究上,以确定前列腺癌治疗的天然产品.
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