良性前列腺增生和尿道癌的风险:基于英国生物银行的一项前性队列研究
Jinjing Guo1, Liang Zhou1, Jiaming He1
1Department of Urology, The Third Xiangya Hospital of Central South University, 138 Tongzipo Road, Changsha, 410013, Hunan, China.
Discover oncology
|September 29, 2025
概括
良性前列腺增生 (BPH) 增加前列腺,膀和癌的风险. 乙PH与前列腺癌和膀癌有因果关系,特别是在年长的,具有足够体力活动的白人个体中.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 在瘤学瘤学.
- 流行病学 流行病学
背景情况:
- 良性前列腺增生 (BPH) 是尿道癌的潜在危险因素,但证据不确定.
- 这项研究调查了BPH与发生尿道癌的风险之间的关联,包括前列腺癌 (PCa),膀癌 (BCa) 和细胞癌 (RCC).
研究的目的:
- 评估BPH和尿道癌症风险之间的关系.
- 探索BPH与PCa,BCa和RCC风险之间的潜在因果关系.
主要方法:
- 利用了来自190,829名参与者的英国生物库数据 (2006-2010年).
- 使用Cox比例危险回归和倾向得分匹配 (PSM) 来分析风险.
- 进行了两样本的孟德尔随机化 (MR) 分析以确定因果关系.
主要成果:
- BPH与PCa (PSM后HR 1.30),BCa (PSM后HR 1.92) 和RCC (PSM后HR 1.41) 的风险显著增加.
- MR分析表明,BPH对PCa (OR 1.002) 和BCa (OR 1.001) 有积极的因果作用.
- 在老年人,白人和具有足够体力活动的人群中,BPH和PCa/BCa之间的关联更为强烈.
结论:
- 患有BPH的人面临PCa,RCC和BCa的风险增加.
- 在BPH和PCa和BCa的风险增加之间存在显著的因果关系.
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