侧脑甲突发刺激可以调节自闭症成年人的默认模式网络连接
Hsing-Chang Ni1,2, Heng Chien3, Chun-Hung Yeh1,4
1Department of Psychiatry, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan.
Cerebellum (London, England)
|September 29, 2025
概括
针对小脑的间歇性甲突发刺激 (iTBS) 对自闭症成年人来说是安全的和可行的. 这种神经调节方法可能会严重改变大脑网络连接,这表明未来自闭症症状治疗的潜力.
科学领域:
- 神经科学是一个神经科学.
- 神经调节是一种神经调节.
- 自闭症谱系障碍研究研究
背景情况:
- 核心自闭症症状需要有效的神经调节策略.
- 侧侧小脑与自闭症影响的社会认知功能有关.
- 重复性横磁性刺激 (rTMS) 尚未被测试用于自闭症中小脑向.
研究的目的:
- 为了研究间歇性甲爆刺激 (iTBS) 的安全性和可行性,针对自闭症成年人的右侧小脑.
- 探索小脑iTBS对大脑功能连接的急性网络级影响.
- 评估iTBS对大规模大脑网络中的功能连接特征的影响.
主要方法:
- 一项试点研究涉及10名自闭症成年人 (19-30岁).
- 对右侧小脑 (Crus I/II) 进行了一次iTBS (1200次脉冲,80%的活跃运动值).
- 休息状态功能性MRI (fMRI) 用于在iTBS之前和之后评估功能连接的变化.
主要成果:
- 该iTBS协议被很好地容忍,没有严重的不良事件和100%的保留率.
- 在默认模式网络和体感官运动网络中观察到iTBS后功能连接的显著下降.
- 功能连接的特异性在几个网络中下降,包括腹部注意力,前端对称,默认模式和视觉网络.
结论:
- 大脑小脑iTBS是一种安全且可行的自闭症成年人的神经调节技术.
- 单个会话的小脑iTBS可以敏调节多个大规模的大脑功能网络.
- 需要进一步进行多次,模拟控制的试验来证实这些发现,并探索自闭症的持续临床益处.
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